Lack of effect of drinking water barium on cardiovascular risk factors.
Lack of effect of drinking water barium on cardiovascular risk factors.
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DOI：
10.1289/ehp.85-1568324
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发表时间：
1990-04
影响因子：
10.4
通讯作者：
Frohman LA
中科院分区：
文献类型：
--
作者：
Wones RG;Stadler BL;Frohman LA
一项流行病学研究表明，较高的心血管死亡率与饮用水中较高的钡含量有关。本研究的目的是确定美国一些社区饮用水中的钡含量是否会改变已知的心血管疾病危险因素。 11 名健康男性完成了为期 10 周的剂量反应方案，其中控制饮食（600 毫克胆固醇；40% 脂肪、40% 碳水化合物、20% 蛋白质；钠和钾控制在受试者方案前的估计摄入量）。控制受试者生活方式中已知影响心脏危险因素的其他方面，饮用水（1.5升/天）的钡含量（氯化钡）从0（前2周）、5 ppm（接下来4周）到10 ppm（最后4周）变化。每个剂量的钡剂均进行多份血液和尿液样本、早晚血压测量以及 48 小时心电图监测。早晨或晚上的收缩压或舒张压、血浆胆固醇或脂蛋白或载脂蛋白水平、血清钾或葡萄糖水平或尿液儿茶酚胺水平没有变化。连续心电图监测未发现与钡暴露相关的心律失常。暴露于钡后观察到总血清钙水平增加的趋势，其具有临界统计显着性且临床意义值得怀疑。总之，饮用水中钡浓度为 5 和 10 ppm 似乎不会影响任何已知的可改变的心血管危险因素。
Higher cardiovascular mortality has been associated in a single epidemiological study with higher levels of barium in drinking water. The purpose of this study was to determine whether drinking water barium at levels found in some U.S. communities alters the known risk factors for cardiovascular disease. Eleven healthy men completed a 10-week dose-response protocol in which diet was controlled (600 mg cholesterol; 40% fat, 40% carbohydrate, 20% protein; sodium and potassium controlled at the subject's pre-protocol estimated intake). Other aspects of the subjects' lifestyles known to affect cardiac risk factors were controlled, and the barium content (as barium chloride) of the drinking water (1.5 L/day) was varied from 0 (first 2 weeks), to 5 ppm (next 4 weeks), to 10 ppm (last 4 weeks). Multiple blood and urine samples, morning and evening blood pressure measurements, and 48-hr electrocardiographic monitoring were performed at each dose of barium. There were no changes in morning or evening systolic or diastolic blood pressures, plasma cholesterol or lipoprotein or apolipoprotein levels, serum potassium or glucose levels, or urine catecholamine levels. There were no arrhythmias related to barium exposure detected on continuous electrocardiographic monitoring. A trend was seen toward increased total serum calcium levels with exposure to barium, which was of borderline statistical significance and of doubtful clinical significance. In summary, drinking water barium at levels of 5 and 10 ppm did not appear to affect any of the known modifiable cardiovascular risk factors.