Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
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DOI：
10.1126/science.272.5267.1502
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发表时间：
1996-06-07
期刊：
影响因子：
56.9
通讯作者：
Duffy, PE
中科院分区：
文献类型：
--
作者：
Fried, M;Duffy, PE
妇女在第一次和第二次怀孕期间特别容易感染疟疾，即使她们在流行地区居住多年可能已经形成了免疫力。恶性疟原虫感染红细胞(IRBCs)是从人胎盘中提取的。这些IRBCs与纯化的硫酸软骨素A(CsA)结合，但不与其他细胞外基质蛋白或其他已知的IRBC受体结合。来自非妊娠供者的IRBCs不与CsA结合。新鲜冰冻人胎盘切片上的IRBCs与自然感染的胎盘具有相似的解剖分布，纯化的CsA竞争性地抑制了这种黏附。因此，对环孢素A的黏附似乎选择了导致母体疟疾的寄生虫亚群。
Women are particularly susceptible to malaria during first and second pregnancies, even though they may have developed immunity over years of residence in endemic areas. Plasmodium falciparum-infected red blood cells (IRBCs) were obtained from human placentas. These IRBCs bound to purified chondroitin sulfate A (CSA) but not to other extracellular matrix proteins or to other known IRBC receptors. IRBCs from nonpregnant donors did not bind to CSA. Placental IRBCs adhered to sections of fresh-frozen human placenta with an anatomic distribution similar to that of naturally infected placentas, and this adhesion was competitively inhibited by purified CSA. Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria.