Seizure abatement with Single DC Pulses: is Phase resetting at Play?
Seizure abatement with Single DC Pulses: is Phase resetting at Play?
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DOI：
10.1142/s0129065709001926
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发表时间：
2009-06
影响因子：
8
通讯作者：
I. Osorio;M. Frei
中科院分区：
文献类型：
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作者：
I. Osorio;M. Frei
癫痫发作减少的拓扑方法很少受到关注。重置生物振荡相位的能力已被广泛应用于心脏病学，部分证据是植入式除颤器的有用性，但不是在癫痫学。本工作的目的是研究使用单个或短暂的单相（DC）脉冲序列阻断癫痫发作的可行性。单DC或简短的（0.1秒）脉冲串手动或自动传递到全身性癫痫发作，在大鼠与惊厥3-巯基丙酸，GABA抑制剂诱导。治疗结果（阻断与未阻断的癫痫发作）通过视觉确定，并与“节律指数”相关，这是神经元同步水平的间接估计。对于节律性指数> 0.6的癫痫发作，使用单个或短暂（0.1 s）DC脉冲的阻断始终实现，而水平<0.6的癫痫发作则没有，尽管其振荡中的瞬时相位变化受到影响。这项工作揭示了神经元同步化水平可能是决定癫痫发作阻滞概率的重要因素。单脉冲或短脉冲阻断癫痫发作及其对神经组织的影响值得进一步研究。这种治疗方式和手段，以提高它的临床适用性进行了讨论。
Topological approaches for seizure abatement have received scarce attention. The ability to reset the phase of biological oscillations has been widely exploited in cardiology, as evidenced in part by the usefulness of implantable of defibrillators, but not in epileptology. The aim of this work is to investigate the feasibility of seizure blockage using single or brief monophasic (DC) pulse trains. Single DC or brief (0.1 s) pulse trains were delivered manually or automatically to generalized seizures, induced in rats with the convulsant 3-mercaptoprionic acid, a GABA inhibitor. Treatment outcome (blocked vs. not blocked seizures) was ascertained visually and correlated with the "rhythmicity index", an indirect estimate of neuronal synchrony level. Blockage using single or brief (0.1 s) DC pulses was consistently achieved for seizures with a rhythmicity index > 0.6, while seizures with levels <0.6 were not, although transient phase changes in their oscillations were effected. This work reveals that level of neuronal synchronization may be an important factor in determining the probability of seizure blockage. Seizure blockage using single or brief DC pulse trains and its effects on neural tissue merit further investigation. The clinical applicability of this therapeutic modality and means to enhance it are discussed.