Zika and Chikungunya Virus and Risk for Venous Thromboembolism
Zika and Chikungunya Virus and Risk for Venous Thromboembolism
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DOI：
10.1177/1076029618821184
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发表时间：
2019-01-28
影响因子：
2.9
通讯作者：
Fareed, Jawed
中科院分区：
文献类型：
--
作者：
Ramacciotti, Eduardo;Agati, Leandro B.;Fareed, Jawed
多种病毒感染与高凝状态有关，并可能与深静脉血栓形成和肺栓塞的发生有关。寨卡和基孔肯雅病毒感染在南美洲和中美洲大陆传播，2016年转移到北美，严重的多关节痛，发烧和格林-巴利综合征病例最终导致死亡。据报告，2017年第一季度这两种感染呈下降趋势。在这篇文章中，我们报告了与寨卡病毒感染相关的静脉血栓栓塞事件的可能关联。在2例急性寨卡病毒感染患者发生深静脉血栓形成后，对巴西流行地区一所大学医院急诊科的172名连续患者进行了D-二聚体水平测定，这些患者经聚合酶链反应测试证实患有寨卡病毒或基孔肯雅病毒感染。31名寨卡病毒感染者中有19.4%的人D-二聚体水平升高，141名基孔肯雅病毒感染者中有63.8%的人D-二聚体水平升高。这种关联背后的机制尚未阐明，以及受寨卡病毒和基孔肯雅病毒感染影响的住院患者静脉血栓栓塞预防策略的潜力。
A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barre syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections.