A novel system exploits bone debris for implant osseointegration
A novel system exploits bone debris for implant osseointegration
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DOI：
10.1002/jper.20-0099
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发表时间：
2020-09-10
影响因子：
4.3
通讯作者：
Helms, Jill A.
中科院分区：
文献类型：
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作者：
Coyac, Benjamin R.;Salvi, Giuseppe;Helms, Jill A.
背景：在种植体预备过程中产生的骨碎片通常通过冲洗排出;在此，我们评估了保留这种自体材料是否能提高种植体周围骨形成的速度。方法在25只大鼠中，将由骨成形工具和三椭圆形种植体组成的微型种植体系统与传统的钻头和圆形种植体系统进行比较。采用裂口设计，新鲜拔牙窝作为种植部位。在种植体植入后立即以及术后第3、7、14和28天进行组织学/组织形态计量学、免疫组织化学和显微计算机断层扫描（mu CT）成像。结果与传统钻头设计相比，骨成形工具产生了纹理化截骨表面和保留在种植体周围环境中的活性骨碎片。通过PCNA和Runx 2表达鉴定的增殖性骨祖细胞有助于更快的种植体周围骨形成。虽然所有种植体骨整合，与对照组相比，骨成形工具准备的部位显示出种植体周围新骨的证据。结论骨成形工具产生的骨碎片直接促进种植体周围骨形成和种植体骨结合。
Background Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri-implant bone formation. Methods In 25 rats, a miniature implant system composed of an osseo-shaping tool and a tri-oval-shaped implant was compared against a conventional drill and round implant system. A split-mouth design was used, and fresh extraction sockets served as implant sites. Histology/histomorphometry, immunohistochemistry, and microcomputed tomography (mu CT) imaging were performed immediately after implant placement, and on post-surgery days 3, 7, 14, and 28. Results Compared with a conventional drill design, the osseo-shaping tool produced a textured osteotomy surface and viable bone debris that was retained in the peri-implant environment. Proliferating osteoprogenitor cells, identified by PCNA and Runx2 expression, contributed to faster peri-implant bone formation. Although all implants osseointegrated, sites prepared with the osseo-shaping tool showed evidence of new peri-implant bone sooner than controls. Conclusion Bone debris produced by an osseo-shaping tool directly contributed to faster peri-implant bone formation and implant osseointegration.