INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN
INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN
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DOI：
10.1111/j.1476-5381.1976.tb07446.x
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发表时间：
1976-01-01
影响因子：
7.3
通讯作者：
KINGSTON, WP
中科院分区：
文献类型：
--
作者：
FLOWER, RJ;HARVEY, EA;KINGSTON, WP
1在人前臂皮内注射前列腺素（PG）D1和D2，产生持久的剂量相关性红斑。与前列腺素E1或E2相比，产生红斑的效力顺序为PGE 1大于PGE 2大于PGD 2大于PGD 1。2用伊文思蓝法和~（125）I-白蛋白外渗法测定，前列腺素D_2可引起大鼠皮肤血管通透性增加，而D_1无此作用。前列腺素E2的效力是前列腺素D2的3-5倍。3前列腺素D_2（10 ng）可增强组胺引起的大鼠皮肤血管通透性增加，但对缓激肽引起的血管通透性增加无明显作用。4前列腺素D2（10、20和50 ng）在大鼠足水肿试验中未引起水肿或痛觉过敏，但增强角叉菜胶诱导的水肿; 100 ng及以上剂量增强痛觉过敏。
1 Intradermal injection of prostaglandin (PG) D1 and D2 in the human forearm produced a long-lasting dose-related erythema. When compared with prostaglandin E1 or E2 the order of potency for erythema production was PGE1 greater than PGE2 greater than PGD2 greater than PGD1. 2 In rat skin, prostaglandin D2 but not D1 caused an increase in vascular permeability as quantitated by the Evans blue method and the 125I-albumin extravasation technique. Prostaglandin E2 was 3-5 times more potent than prostaglandin D2. 3 Prostaglandin D2 (10 ng) potentiated the increase in vascular permeability in rat skin produced by histamine, but not that produced by bradykinin. 4 Prostaglandin D2 (10, 20 and 50 ng) did not elicit oedema or hyperalgesia in the rat paw oedema test, but potentiated carrageenan-induced oedema; hyperalgesia was potentiated by doses of 100 ng and above.