Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants
Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants
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DOI：
10.1128/jvi.76.1.432-435.2002
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发表时间：
2002-01-01
影响因子：
5.4
通讯作者：
Coutelier, JP
中科院分区：
文献类型：
--
作者：
Markine-Goriaynoff, D;Coutelier, JP
免疫球蛋白 GI (IgG1)、IgG2a 和 IgG2b 开关变体源自针对乳酸脱氢酶升高病毒 (LDV) VP3 包膜糖蛋白的 IgG3 单克隆抗体。在四种抗体中，IgG2a 比其他亚类更能延迟 LDV 诱导的脊髓灰质炎脑脊髓炎的发病和进展。这表明，在活病毒引起的许多 IgG 抗体反应中观察到的 IgG2a 优势可能至少在某些情况下对应于对受感染宿主的最佳保护的选择。
Immunoglobulin GI (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.