Biomimetic potassium-selective nanopores
Biomimetic potassium-selective nanopores
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DOI：
10.1126/sciadv.aav2568
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发表时间：
2019-02-01
期刊：
影响因子：
13.6
通讯作者：
Siwy, Zuzanna S.
中科院分区：
文献类型：
--
作者：
Acar, Elif Turker;Buchsbaum, Steven F.;Siwy, Zuzanna S.
在人工纳米孔系统中再现生物离子通道所显示的精致的离子选择性已被证明是纳米孔界所承担的最具挑战性的任务之一，然而这一目标的成功实现提供了巨大的技术潜力。在这里，我们展示了一种设计固态纳米孔的策略，该纳米孔选择性地传输钾离子，并且对钠离子表现出可忽略的电导。纳米孔包含用4 '-氨基苯并-18-冠-6醚和位于一个孔入口处的单链DNA（ssDNA）分子装饰的壁。离子选择性源于钾离子在含有冠醚的孔区域中的促进运输，而高电荷的ssDNA起阳离子过滤器的作用。在固态纳米孔中实现钾的选择性为先进的分离过程、更有效的生物传感技术和新型仿生纳米孔系统开辟了新的途径。
Reproducing the exquisite ion selectivity displayed by biological ion channels in artificial nanopore systems has proven to be one of the most challenging tasks undertaken by the nanopore community, yet a successful achievement of this goal offers immense technological potential. Here, we show a strategy to design solid-state nanopores that selectively transport potassium ions and show negligible conductance for sodium ions. The nanopores contain walls decorated with 4'-aminobenzo-18-crown-6 ether and single-stranded DNA (ssDNA) molecules located at one pore entrance. The ionic selectivity stems from facilitated transport of potassium ions in the pore region containing crown ether, while the highly charged ssDNA plays the role of a cation filter. Achieving potassium selectivity in solid-state nanopores opens new avenues toward advanced separation processes, more efficient biosensing technologies, and novel biomimetic nanopore systems.