A genetic approach to the study of lung physiology: understanding biological variability in airway responsiveness.
A genetic approach to the study of lung physiology: understanding biological variability in airway responsiveness.
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研究肺生理学的遗传学方法：了解气道反应性的生物变异性。
DOI：
10.1152/ajplung.1990.258.4.l157
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
S. Kleeberger
中科院分区：
文献类型：
--
作者：
R. Levitt;W. Mitzner;S. Kleeberger
遗传技术一般适用于几乎任何可以证明生物变异性的性状或生理过程。然而，这些方法通常不适用于肺病理生理学的研究。这篇评论的目的是介绍和讨论遗传学方法在哮喘病理生理学研究中的潜在应用。将回顾最近在遗传标准化近交实验室小鼠中鉴定决定气道高反应性的基因的努力。这些实验证明了遗传背景如何影响气道对某些环境刺激的反应性的表达，并说明了所选遗传资源的应用。下面讨论这些遗传模型如何可能提供深入了解哮喘和我们的理解的分子生理学和遗传调节气道高反应性的各种刺激。
Genetic techniques are generally applicable to almost any trait or physiological process for which biological variability can be demonstrated. These methods have not commonly been applied to studies on lung pathophysiology, however. The aim of this commentary will be to introduce and discuss the potential application of genetic methods to research on the pathophysiology of asthma. Recent efforts to identify genes that determine airway hyperresponsiveness in the genetically standardized inbred laboratory mouse will be reviewed. These experiments demonstrate how genetic background influences the expression of airway responsiveness to certain environmental stimuli and illustrate the application of selected genetic resources. A discussion follows on how these genetic models may potentially provide insight into asthma and our understanding of the molecular physiology and genetic regulation of airway hyperreactivity to various stimuli.