Delayed apperance of anti–myelin‐associated glycoprotein antibodies in a patient with chronic demyelinating polyneuropathy
Delayed apperance of anti–myelin‐associated glycoprotein antibodies in a patient with chronic demyelinating polyneuropathy
复制标题
慢性脱髓鞘性多发性神经病患者抗髓鞘相关糖蛋白抗体延迟出现
DOI：
10.1002/ana.410340314
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发表时间：
1993
影响因子：
11.2
通讯作者：
Diana Graus
中科院分区：
文献类型：
--
作者：
MD F. Valldeoriola;F. Graus;A. Steck;MD E. Munoz;MD Tui. de la Fuente;I. T. Gallart;MD T. Ribalta;MD J. A. Bombi;MD E. Tolosa;Mutioz E Steck AJ;Diana Graus
一名患有多发性神经病的患者与慢性炎性脱髓鞘性多发性神经病相一致，并且最初抗髓鞘相关糖蛋白（MAG）抗体呈阴性，在诊断后两年内发展为双单克隆丙种球蛋白病，IgM κ和IgM λ。IgM κ，而不是IgM λ，表现出强的抗MAG抗体活性。抗MAG免疫反应性的晚期出现表明，在初步诊断为慢性炎性脱髓鞘性多发性神经病的患者中，应在神经病过程中重复寻找抗MAG抗体。
A patient who had a polyneuropathy compatible with a chronic inflammatory demyelinating polyneuropathy and was initially negative for anti‐myelin‐associated glycoprotein (MAG) antibodies developed a double monoclonal gammopathy, IgM kappa and IgM lambda, two years after the diagnosis. The IgM kappa, but not the IgM lambda, exhibited strong anti‐MAG antibody activity. The late appearance of the anti‐MAG immunoreactivity suggests that in patients with an initial diagnosis of chronic inflammatory demyelinating polyneuropathy, the search for anti‐MAG antibodies should be repeated during the course of the neuropathy.