Reactions of 5-HT neurons to drugs of abuse: neurotoxicity and plasticity.
Reactions of 5-HT neurons to drugs of abuse: neurotoxicity and plasticity.
复制标题
5-HT 神经元对滥用药物的反应：神经毒性和可塑性。
DOI：
10.1037/e495922006-009
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Molliver,ME
中科院分区：
文献类型：
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作者：
Wilson,MA;Mamounas,LA;Fasman,KH;Axt,KJ;Molliver,ME
Many drugs of abuse that have mood-altering, mood-elevating, or hallucinogenic effects have direct pharmacologic actions on serotonergic (5-HT) neurons, particularly at 5-HT synaptic terminals (Aghajanian et al. 1970; McCall and Aghajanian 1980; Trulson et al. 1981; Jacobs 1984; Glennon et al. 1984; Rasmussen and Aghajanian 1986; Fuller 1986; Campbell et al. 1987). Several of the psychotropic amphetamine derivatives, such as p-chloroamphetamine (PCA), 3, 4-methylenedioxyamphetamine (MDA), 3, 4-methylenedioxymethamphetamine (MDMA), and fenfluramine, have been shown to release 5-HT from serotonergic axon terminals (Gallager and Sanders-Bush 1973; Sanders-Bush and Martin 1982; Fattaccini et al. 1991; Johnson et al. 1991) and can also cause 5-HT axon terminals to degenerate (Battaglia et al. 1987; O’Hearn et al. 1988; Mamounas and Molliver 1988; Molliver and Molliver 1990). However, unlike 5, 7-dihydroxytryptamine (5, 7-DHT), which is neurotoxic to all types of serotonergic axons as well as serotonergic cell bodies, the amphetamine derivatives have selective neurotoxic effects that are restricted to a particular subset of 5-HT axons. Furthermore, the vulnerable and resistant axons can be distinguished on the basis of anatomic characteristics (O’Hearn et al. 1988; Wilson et al. 1989; Mamounas et al. 1991).
