The coexistence of protozoan-like parasites and meningoencephalitis in mice.
The coexistence of protozoan-like parasites and meningoencephalitis in mice.
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DOI：
10.1084/jem.40.1.51
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发表时间：
1924-07-01
影响因子：
15.3
通讯作者：
Nicholson, FM
中科院分区：
文献类型：
--
作者：
Cowdry, EV;Nicholson, FM
一小部分看似正常的实验室小鼠实际上患的是一种不明疾病，其特征是存在明显的脑膜脑病损害，通常伴有原生动物样寄生虫。这些病变和寄生虫都与以前在兔子身上报道的其他疾病非常相似，同样没有通过明显的临床症状显示出来。在缺乏直接实验证据的情况下，有人认为，要么是一种寄生虫能够在两种动物身上造成病变，要么是两种密切相关的寄生虫，在迄今为止观察到的阶段，它们彼此无法区分。
A small proportion of laboratory mice, which appear to be normal, are in reality suffering from an obscure disease characterized by the presence of marked meningoencephalitic lesions which are often accompanied by protozoan-like parasites. Both the lesions and the parasites closely resemble others previously reported in rabbits, which likewise fail to reveal themselves by pronounced clinical symptoms. In the absence of direct experimental evidence it is suggested either that one species of parasite is capable of producing the lesions in both animals, or else that we have to do with two kinds of parasites which are closely related and, in the stages thus far observed, are indistinguishable one from the other.