Local staging of prostate cancer using magnetic resonance imaging: a meta-analysis
Local staging of prostate cancer using magnetic resonance imaging: a meta-analysis
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DOI：
10.1007/s00330-002-1389-z
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发表时间：
2002-09-01
影响因子：
5.9
通讯作者：
Barentsz, JO
中科院分区：
文献类型：
--
作者：
Engelbrecht, MR;Jager, GJ;Barentsz, JO
我们的目的是确定患者、研究设计和成像方案特征对前列腺癌磁共振成像分期表现的影响。在电子文献检索和参考书目回顾（1984年1月至2000年5月）中，选定的文章包括对局部分期的敏感性和特异性的数据。亚组分析考察了年龄、前列腺特异性抗原、肿瘤分级、激素预处理、分期分布、发表年份、来源部门、验证偏倚、活检和MR成像间隔时间的影响；共识阅读、研究设计、连续患者、样本量、组织学准备、成像平面、快速自旋回波、脂肪抑制、直肠内线圈、场强度、分辨率、胰高血糖素、造影剂、磁共振波谱和动态增强MRI。纳入71篇文章和5篇摘要，共146项研究。缺失值在患者特征和研究设计方面非常普遍。出版年份、样本量、组织学金标准、成像平面数、涡轮旋转回波、直肠内线圈和造影剂影响分期表现（p=0.05）。由于报告不足，不可能完全解释文献中表现的异质性。我们的研究结果表明，涡轮自旋回波、直肠内线圈和多个成像平面可改善分期表现。小样本量的研究可能导致更高的分期表现。
Our objective was to determine the influence of patient-, study design-, and imaging protocol characteristics on staging performance of MR imaging in prostate cancer. In an electronic literature search and review of bibliographies (January 1984 to May 2000) the articles selected included data on sensitivity and specificity for local staging. Subgroup analyses examined the influence of age, prostate specific antigen, tumor grade, hormonal pretreatment, stage distribution, publication year, department of origin, verification bias, time between biopsy and MR imaging; consensus reading, study design, consecutive patients, sample size, histology preparation, imaging planes, fast spin echo, fat suppression, endorectal coil, field strength, resolution, glucagon, contrast agents, MR spectroscopy, and dynamic contrast-enhanced MRI. Seventy-one articles and five abstracts were included, yielding 146 studies. Missing values were highly prevalent for patient characteristics and study design. Publication year, sample size, histologic gold standard, number of imaging planes, turbo spin echo, endorectal coil, and contrast agents influenced staging performance (p=0.05). Due to poor reporting it was not possible to fully explain the heterogeneity of performance presented in the literature. Our results suggest that turbo spin echo, endorectal coil, and multiple imaging planes improve staging performance. Studies with small sample sizes may result in higher staging performance.