The Regulation of Cell Behavior by Cell Adhesion
The Regulation of Cell Behavior by Cell Adhesion
复制标题
细胞粘附对细胞行为的调节
DOI：
10.1007/978-1-4684-9933-9_6
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发表时间：
1980
期刊：
影响因子：
64.8
通讯作者：
M. Bernfield
中科院分区：
文献类型：
--
作者：
Paul C. Letourneau;P. Ray;M. Bernfield
组织的复杂形态发生及其在生物体内平衡中的成功参与取决于组织细胞与其环境的调节相互作用。可溶性外源性分子对基因表达的影响最好地由激素的强大作用来说明。几乎所有细胞与其他细胞或细胞外结构的接触和物理联系，虽然不太为人所知，但对基因表达也有重要影响。这些关联对细胞功能的重要性知之甚少，因为它们不容易在原位操作或评估，即使在体外复制，也必须确定细胞接触的哪些方面是调节性的。
The complex morphogenesis of tissues and their successful participation in an organism’s homeostasis depend on regulatory interactions of the tissue cells with their environment. The influence of soluble extrinsic molecules on genetic expression is best illustrated by the powerful effects of hormones. Less well appreciated but also with significant effects on genetic expression are the contacts and physical associations that nearly all cells make with other cells or with extracellular structures. The importance of these associations to cell function is poorly understood, because they are not easily manipulated or assessed in situ, and even when duplicated in vitro one must determine which aspects of cellular contact are regulatory.