Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia
Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia
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DOI：
10.1001/archpsyc.64.7.772
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发表时间：
2007-07-01
影响因子：
--
通讯作者：
Rapoport, Judith
中科院分区：
文献类型：
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作者：
Gogtay, Nitin;Greenstein, Deanna;Rapoport, Judith
内容：皮质灰质（GM）的损失是显着的，并在儿童期发病的精神分裂症（COS）在青春期进行，但变得更加局限于成年早期。COS先证者的非精神病兄弟姐妹可以帮助评估皮质GM异常是否是家族/特质标记。目的：绘制COS先证者的非精神病兄弟姐妹的皮质发育。设计：使用自动测量和前瞻性获得的解剖脑磁共振图像，我们绘制了健康完整兄弟姐妹的皮质GM厚度（n = 52，113次扫描;年龄8 - 28岁）的COS患者，将其与年龄，性别和扫描间隔匹配的健康对照组（n = 52，108次扫描）进行对比。错误发现率程序被用来控制I型错误，由于多重比较。设置：一个正在进行的COS研究在国家精神卫生研究所。参与者：52名健康的全同胞的COS患者，年龄从8岁到28岁，和52名健康对照。主要结果测量：COS患者健康同胞与匹配健康对照组皮质GM发育的纵向轨迹及发育GM之间关系的探索性测量结果：与对照组相比，COS患者的年轻健康同胞在左前额叶和双侧颞叶皮质表现出明显的GM缺陷，而在右前额叶和顶叶下部皮质表现出较小的缺陷。兄弟姐妹的这些皮质缺陷在20岁时消失，并且缺陷减少的过程与最后一次扫描时的整体功能（GAS评分）相关。结论：COS中的前额和颞叶GM丢失似乎是一个家族/特征标记。在健康的兄弟姐妹中，区域GM缺陷的改善与更高的整体功能（GAS评分）相关，这表明这些非精神病性、非谱系的兄弟姐妹的大脑可塑性和功能结果之间存在关系。
Context: Cortical gray matter ( GM) loss is marked and progressive in childhood-onset schizophrenia (COS) during adolescence but becomes more circumscribed by early adulthood. Nonpsychotic siblings of COS probands could help evaluate whether the cortical GM abnormalities are familial/trait markers.Objective: To map cortical development in nonpsychotic siblings of COS probands.Design: Using an automated measurement and prospectively acquired anatomical brain magnetic resonance images, we mapped cortical GM thickness in healthy full siblings (n = 52, 113 scans; age 8 through 28 years) of patients with COS, contrasting them with age-, sex-, and scan interval-matched healthy controls (n = 52, 108 scans). The false-discovery rate procedure was used to control for type I errors due to multiple comparisons.Setting: An ongoing COS study at the National Institute of Mental Health.Participants: Fifty-two healthy full siblings of patients with COS, aged 8 through 28 years, and 52 healthy controls.Main Outcome Measures: Longitudinal trajectories of cortical GM development in healthy siblings of patients with COS compared with matched healthy controls and exploratory measure of the relationship between developmental GM trajectories and the overall functioning as defined by the Global Assessment Scale (GAS) score.Results: Younger, healthy siblings of patients with COS showed significant GM deficits in the left prefrontal and bilateral temporal cortices and smaller deficits in the right prefrontal and inferior parietal cortices compared with the controls. These cortical deficits in siblings disappeared by age 20 years and the process of deficit reduction correlated with overall functioning (GAS scores) at the last scan.Conclusions: Prefrontal and temporal GM loss in COS appears to be a familial/trait marker. Amelioration of regional GM deficits in healthy siblings was associated with higher global functioning ( GAS scores), suggesting a relationship between brain plasticity and functional outcome for these nonpsychotic, nonspectrum siblings.