Alteration of lymphoid cells in AKR mice by treatment with monoclonal antibody against Thy-1 antigen.
Alteration of lymphoid cells in AKR mice by treatment with monoclonal antibody against Thy-1 antigen.
复制标题
用抗 Thy-1 抗原的单克隆抗体治疗 AKR 小鼠淋巴细胞的改变。
DOI：
10.1097/00007890-198203000-00012
复制
发表时间：
1982
期刊：
影响因子：
6.2
通讯作者：
Nowinski,RC
中科院分区：
文献类型：
--
作者：
Tam,MR;Bernstein,ID;Nowinski,RC
用高水平的单克隆抗Thy-1.1抗体和C处理的AKR/J小鼠保持健康，没有明显的副作用。对这些小鼠的淋巴器官的检查表明淋巴结和脾脏中的T细胞选择性耗竭。停止治疗后，循环中抗Thy-1.1抗体的水平下降，外周淋巴器官逐渐重新充满T细胞。无论C是否与抗体一起沿着输注，淋巴结都会发生耗竭。尽管这些小鼠的胸腺细胞被抗Thy-1.1抗体包被，但它们没有被治疗消除。外周T细胞的消除而不是胸腺T细胞的消除表明辅助因子（可能是抗体依赖性效应细胞）穿透的胸腺屏障，或者抗体通过干扰通常“归巢”淋巴结和脾脏的外周T细胞的正常运输而起作用。
AKR/J mice treated with high levels of monoclonal anti-Thy-1.1 antibody and C remained healthy without apparent side effects. Examination of the lymphatic organs of these mice demonstrated a selective depletion of T cells in lymph nodes and spleen. Following cessation of treatment of the levels of anti-Thy-1.1 antibody in the circulation fell and the peripheral lymphatic organs gradually became repopulated with T cells. Depletion occurred in lymph nodes whether or not C was infused along with the antibody. Although the thymocytes of these mice were coated with anti-Thy-1.1 antibody they were not eliminated by the treatment. The elimination of peripheral but not thymic T cells suggests either a thymic barrier to the penetration of cofactors (possibly antibody-dependent effector cells) or that antibody acts by interfering with the normal traffic of peripheral T cells which normally “home” to the lymph nodes and spleen.