Fibrin‐based biomaterial systems to enhance anterior cruciate ligament healing
Fibrin‐based biomaterial systems to enhance anterior cruciate ligament healing
复制标题
基于纤维蛋白的生物材料系统可增强前十字韧带愈合
DOI：
10.1002/mds3.10147
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Brown, Ashley C.
中科院分区：
文献类型：
--
作者：
Scull, Grant;Fisher, Matthew B.;Brown, Ashley C.
前交叉韧带（ACL）撕裂是一种常见的，可能会导致职业生涯结束的损伤，特别是对于运动员和士兵。该韧带的部分和完全断裂导致膝关节不稳定，并且ACL不具有愈合能力，部分原因是其在膝关节的高度溶血栓的滑液环境中的位置。传统的ACL重建方法，如移植物置换，可以恢复稳定性，但不能防止创伤后骨关节炎的发展。为了增强治疗选择，最近已经探索了新的基于纤维蛋白的技术和修复技术，并显示出改善患者结局的前景。通过修改现有的手术方法，如使用纤维蛋白胶掺入生长因子和细胞，并实施含有富含血小板的血浆，富含血小板的纤维蛋白和其他血液衍生物的支架，外科医生正试图克服传统治疗的缺点。本次小型综述将详细介绍目前使用纤维蛋白治疗的努力，并讨论进一步促进ACL愈合的机会。
Anterior cruciate ligament (ACL) tears are a common and potentially career‐ending injury, particularly for athletes and soldiers. Partial and complete ruptures of this ligament cause instability in the knee, and the ACL does not have the capacity for healing due, in part, to its position within the highly thrombolytic synovial fluid environment of the knee joint. Traditional methods of ACL reconstruction, such as graft replacement, restore stability but do not prevent the development of post‐traumatic osteoarthritis. To enhance therapeutic treatment options, novel fibrin‐based technologies and repair techniques have been recently explored and show promise for improved patient outcomes. Through modification of existing surgical methods, such as the use of fibrin glues incorporating growth factors and cells and the implementation of scaffolds containing platelet‐rich plasma, platelet‐rich fibrin and other blood derivatives, surgeons are attempting to overcome the shortcomings of traditional treatments. This mini‐review will detail current efforts using fibrin‐based treatments and discuss opportunities to further enhance ACL healing.