Human Atlas of the Cardiac Fiber Architecture: Study on a Healthy Population
Human Atlas of the Cardiac Fiber Architecture: Study on a Healthy Population
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DOI：
10.1109/tmi.2012.2192743
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发表时间：
2012-07-01
影响因子：
10.6
通讯作者：
Ayache, Nicholas
中科院分区：
文献类型：
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作者：
Lombaert, Herve;Peyrat, Jean-Marc;Ayache, Nicholas
心脏纤维，以及它们在层状片材中的局部布置，具有它们的取向的复杂空间变化，其在机械和电心脏功能中具有重要作用。在本文中，这种心脏纤维结构的统计图谱首次使用人类数据集建立。该图谱提供了人类心脏纤维结构的平均描述沿着以及其在人群中的变异性。在这项研究中，人口是由10个健康的人的心脏，心脏纤维结构成像离体DT-MRI采集。图集的建设是基于一个计算框架，最大限度地减少用户的互动，并结合了最新的图像分析进展：分割，对称对数域仿形恶魔注册，对数欧几里德度量扩散张量处理和统计分析的图形切割。结果表明，平均纤维取向的螺旋角与透壁深度高度相关，范围从心外膜上的-41度到心内膜上的+66度。此外，我们发现整个群体的纤维取向分散度（+/-13度）低于层状片材（+/-31度）。本研究以人类心脏为基础，扩展了先前对其他哺乳动物的研究，得出了一致的结论，并提供了对人类更具体，更适合临床应用的心脏纤维结构的描述。事实上，该统计图谱可以帮助改进用于射频消融、心脏消融治疗、外科心室修复或由于纤维结构异常引起的心脏疾病的诊断和随访的计算模型。
Cardiac fibers, as well as their local arrangement in laminar sheets, have a complex spatial variation of their orientation that has an important role in mechanical and electrical cardiac functions. In this paper, a statistical atlas of this cardiac fiber architecture is built for the first time using human datasets. This atlas provides an average description of the human cardiac fiber architecture along with its variability within the population. In this study, the population is composed of ten healthy human hearts whose cardiac fiber architecture is imaged ex vivo with DT-MRI acquisitions. The atlas construction is based on a computational framework that minimizes user interactions and combines most recent advances in image analysis: graph cuts for segmentation, symmetric log-domain diffeomorphic demons for registration, and log-Euclidean metric for diffusion tensor processing and statistical analysis. Results show that the helix angle of the average fiber orientation is highly correlated to the transmural depth and ranges from -41 degrees on the epicardium to +66 degrees on the endocardium. Moreover, we find that the fiber orientation dispersion across the population (+/- 13 degrees) is lower than for the laminar sheets (+/- 31 degrees). This study, based on human hearts, extends previous studies on other mammals with concurring conclusions and provides a description of the cardiac fiber architecture more specific to human and better suited for clinical applications. Indeed, this statistical atlas can help to improve the computational models used for radio-frequency ablation, cardiac resynchronization therapy, surgical ventricular restoration, or diagnosis and followups of heart diseases due to fiber architecture anomalies.