In search of multimodal brain alterations in Alzheimer's and Binswanger's disease
In search of multimodal brain alterations in Alzheimer's and Binswanger's disease
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DOI：
10.1016/j.nicl.2019.101937
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Calhoun, Vince D.
中科院分区：
文献类型：
--
作者：
Fu, Zening;Iraji, Armin;Calhoun, Vince D.
痴呆症中的大脑结构和功能异常已被广泛识别，但可复制性存在差异且存在显着重叠。阿尔茨海默病 (AD) 和宾斯旺格病 (BD) 具有相似的症状和常见的大脑变化，可能会混淆诊断。在本研究中，我们旨在通过结合静息态功能磁共振成像 (fMRI) 和扩散 MRI，研究 AD 和 BD 中相关的结构和功能性大脑变化。首先对 fMRI 数据进行组独立成分分析，以提取 49 个内在连接网络 (ICN)。然后，我们对三个特征进行了多集典型相关分析：ICN 之间的功能网络连接性（FNC）、分数各向异性（FA）和平均扩散率（MD）。两个相互关联的成分显示出显着的组间差异。第一个部分展示了 AD 和 BD 之间不同的大脑变化。 AD 显示小脑 FNC 增加，但丘脑和海马 FNC 减少。这种 FNC 改变与胼胝体 FA 减少有关。 AD 的额叶和颞叶皮质的 MD 也有所增加，但 BD 则表现出相反的变化。第二部分展示了 BD 中特定的大脑变化。 FNC 增加主要在默认模式和感觉区域之间，而 FNC 减少主要在默认模式域内且与听觉区域相关。 FNC 的变化与后/中扣带皮层和视觉皮层的 FA 变化以及丘脑和海马 MD 的增加有关。我们的研究结果提供了痴呆症中相关功能和结构缺陷的证据，并表明 AD 和 BD 在白质完整性和功能连接方面既有共同又有独特的变化。
Structural and functional brain abnormalities have been widely identified in dementia, but with variable replicability and significant overlap. Alzheimer's disease (AD) and Binswanger's disease (BD) share similar symptoms and common brain changes that can confound diagnosis. In this study, we aimed to investigate correlated structural and functional brain changes in AD and BD by combining resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI. A group independent component analysis was first performed on the fMRI data to extract 49 intrinsic connectivity networks (ICNs). Then we conducted a multi-set canonical correlation analysis on three features, functional network connectivity (FNC) between ICNs, fractional anisotropy (FA) and mean diffusivity (MD). Two inter-correlated components show significant group differences. The first component demonstrates distinct brain changes between AD and BD. AD shows increased cerebellar FNC but decreased thalamic and hippocampal FNC. Such FNC alterations are linked to the decreased corpus callosum FA. AD also has increased MD in the frontal and temporal cortex, but BD shows opposite alterations. The second component demonstrates specific brain changes in BD. Increased FNC is mainly between default mode and sensory regions, while decreased FNC is mainly within the default mode domain and related to auditory regions. The FNC changes are associated with FA changes in posterior/middle cingulum cortex and visual cortex and increased MD in thalamus and hippocampus. Our findings provide evidence of linked functional and structural deficits in dementia and suggest that AD and BD have both common and distinct changes in white matter integrity and functional connectivity.