Innate allorecognition.
Innate allorecognition.
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DOI：
10.1111/imr.12153
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发表时间：
2014-03
影响因子：
8.7
通讯作者：
Lakkis FG
中科院分区：
文献类型：
--
作者：
Oberbarnscheidt MH;Lakkis FG
脊椎动物对移植的器官(同种异体器官)会产生强烈的适应性免疫反应，但先天免疫系统启动这种反应的机制还不完全清楚。在抗微生物免疫中，与病原体相关但不存在于宿主中的非自身分子通过与生殖系编码的受体结合来诱导先天抗原提呈细胞(APC)成熟。然后，成熟的APC通过呈递微生物抗原并向T细胞提供共刺激信号来启动适应性免疫反应。然而，同种异体移植物如何激活APC尚不清楚，因为同种异体移植物可能是无菌的。一种被广泛接受的观点是，移植时死亡的移植物细胞释放的炎性或危险分子会触发APC成熟和随之而来的T细胞反应。或者，有人提出，在外科手术过程中引入微生物产品也可以提醒先天免疫系统注意移植器官的存在。在这里，我们回顾为什么这些假说不能完全解释移植后同种异体免疫反应是如何启动的，并总结了单核细胞识别同种异体异体是触发同种异体免疫和移植物排斥反应的关键事件的证据。
Vertebrates mount strong adaptive immune responses to transplanted organs (allografts), but the mechanisms by which the innate immune system initiates this response are not completely understood. In anti-microbial immunity, non-self molecules associated with pathogens but not present in the host induce the maturation of innate antigen-presenting cells (APCs) by binding to germ-line-encoded receptors. Mature APCs then initiate the adaptive immune response by presenting microbial antigen and providing costimulatory signals to T cells. How allografts activate APCs, however, is less clear, because allografts are presumably sterile. A widely accepted view is that inflammatory or ‘danger’ molecules released by dying graft cells at the time of transplantation trigger APC maturation and the T-cell response that follows. Alternatively, it has been proposed that the introduction of microbial products during the surgical procedure could also alert the innate immune system to the presence of the transplanted organ. Here we review why these hypotheses fail to fully explain how the alloimmune response is initiated after transplantation and summarize evidence that recognition of allogeneic non-self by monocytes is a key event in triggering alloimmunity and graft rejection.
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DOI：
10.1084/jem.20060376
发表时间：
2006-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
82.9
作者：
Chen, Chun-Jen;Kono, Hajime;Rock, Kenneth L.
通讯作者：
Rock, Kenneth L.
影响因子：
64.8
作者：
BURNET, FM
通讯作者：
BURNET, FM
影响因子：
15.9
作者：
Goldstein, DR;Tesar, BM;Lakkis, FG
通讯作者：
Lakkis, FG
DOI：
10.1073/pnas.0609661104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Ide, Kentaro;Wang, Hui;Ohdan, Hideki
通讯作者：
Ohdan, Hideki