On the evolution of cells
On the evolution of cells
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DOI：
10.1073/pnas.132266999
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发表时间：
2002-06-25
影响因子：
11.1
通讯作者：
Woese, CR
中科院分区：
文献类型：
--
作者：
Woese, CR
提出了细胞组织演化的理论。该模型是基于（数据支持）推测，水平基因转移（HGT）的动态主要是由受体细胞的组织。原住民细胞设计被认为是简单和松散的组织，所有的细胞成分可以通过HGT改变和/或取代，使HGT的早期细胞进化的主要驱动力。原始细胞没有携带稳定的生物体谱系痕迹。原始细胞进化基本上是群体性的。进化细胞设计所需的高水平的新奇是共同发明的产物，是通用HGT领域的产物，而不是系内变异。它是作为一个整体的社区，生态系统，它在进化。然而，以这种方式进化的单个电池设计从根本上是不同的，因为每种情况下的初始条件都有些不同。随着细胞设计变得更加复杂和相互连接，达到了一个临界点，在那里出现了一个更加集成的细胞组织，垂直产生的新奇可以而且确实具有更大的重要性。这个临界点被称为“达尔文阈值”，原因如下。
A theory for the evolution of cellular organization is presented. The model is based on the (data supported) conjecture that the dynamic of horizontal gene transfer (HGT) is primarily determined by the organization of the recipient cell. Aboriginal cell designs are taken to be simple and loosely organized enough that all cellular componentry can be altered and/or displaced through HGT, making HGT the principal driving force in early cellular evolution. Primitive cells did not carry a stable organismal genealogical trace. Primitive cellular evolution is basically communal. The high level of novelty required to evolve cell designs is a product of communal invention, of the universal HGT field, not intralineage variation. It is the community as a whole, the ecosystem, which evolves. The individual cell designs that evolved in this way are nevertheless fundamentally distinct, because the initial conditions in each case are somewhat different. As a cell design becomes more complex and interconnected a critical point is reached where a more integrated cellular organization emerges, and vertically generated novelty can and does assume greater importance. This critical point is called the "Darwinian Threshold" for the reasons given.