Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca2+ in cardiomyocytes?
Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca2+ in cardiomyocytes?
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DOI:
10.1085/jgp.202213078
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发表时间:
2022-09-05
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It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca2+. This commentary discusses new findings supporting the cytosolic Ca2+-dependent regulation.
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