Macrophage balance fraction determines the degree of immunosuppression and metastatic ability of breast cancer.
Macrophage balance fraction determines the degree of immunosuppression and metastatic ability of breast cancer.
复制标题
DOI：
10.1016/j.intimp.2021.107682
复制
发表时间：
2021-04
影响因子：
5.6
通讯作者：
Chao Wang;Minghua Cao;Xiaoli Jiang;Yudi Yao;Zhuoqi Liu;Daya Luo
中科院分区：
文献类型：
--
作者：
Chao Wang;Minghua Cao;Xiaoli Jiang;Yudi Yao;Zhuoqi Liu;Daya Luo
巨噬细胞是肿瘤微环境中重要的免疫细胞，可分为两种极化亚型，M1和M2。M1型巨噬细胞具有抗肿瘤作用，而M2型巨噬细胞具有促肿瘤作用。目前的研究大多局限于M1或M2巨噬细胞对肿瘤的作用，而忽略了巨噬细胞的整体平衡。我们的研究表明，巨噬细胞平衡分数（MBF）能更有效、更全面地反映肿瘤相关巨噬细胞的平衡。通过生物信息学分析和体外实验，我们发现MBF也是乳腺癌免疫抑制程度和转移能力的有效指标，不同MBF环境可以影响乳腺癌细胞的迁移和侵袭能力。最后，我们还发现乳腺癌中MBF变化的机制可能受到乳腺癌源性外泌体的影响。总之，MBF被提出并被验证为巨噬细胞平衡状态的新指标。利用这一指标，我们发现巨噬细胞的平衡可以影响乳腺癌的免疫抑制程度和转移能力。
Macrophages are important immune cells in the tumor microenvironment and can be divided into two polarized subtypes, M1 and M2. M1 type macrophages have anti-tumor effects, while M2 type macrophages have pro-tumor effect. Most of the current researches are limited to the effect of M1 or M2 macrophages on tumors, while ignoring the overall balance of macrophages. Our research suggests that the macrophage balance fraction (MBF) can more effectively and comprehensively reflect the balance of tumor associated macrophages. Using bioinformatics analysis and in vitro experiments, we found that MBF is also an effective indicator of the degree of immunosuppression and metastatic ability of breast cancer, and different MBF environment can impact the migration and invasion ability of breast cancer cells. Finally, we also found that the mechanism of MBF changes in breast cancer may be affected by breast cancer-derived exosomes. In summary, MBF was proposed and validated as a novel indicator of macrophage balance state. Using this indicator, we found that the balance of macrophages can affect the degree of immunosuppression and metastatic ability of breast cancer.