ANDROGEN AND ESTROGEN-RECEPTORS IN HEPATOCELLULAR-CARCINOMA AND SURROUNDING LIVER PARENCHYMA - IMPACT ON INTRAHEPATIC RECURRENCE AFTER HEPATIC RESECTION
ANDROGEN AND ESTROGEN-RECEPTORS IN HEPATOCELLULAR-CARCINOMA AND SURROUNDING LIVER PARENCHYMA - IMPACT ON INTRAHEPATIC RECURRENCE AFTER HEPATIC RESECTION
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DOI：
10.1002/bjs.1800820435
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发表时间：
1995-04-01
影响因子：
9.6
通讯作者：
NAKAMURA, T
中科院分区：
文献类型：
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作者：
NAGASUE, N;YU, L;NAKAMURA, T
78例患者，其中雄激素或雌激素或两者，测定肝细胞癌（HCC）和周围的肝脏出院后，根治性切除肿瘤。随访28-128个月后，对肝内复发进行回顾性评估，以确定与受体状态的相关性。雄激素和雌激素受体对肝内复发率有显著影响。雄激素受体阴性肿瘤患者的5年无复发生存率为55%，雌激素受体阴性为24%，雌激素受体阳性为10%，雄激素受体阳性为0（P = 0.0322）。在57例接受两种受体检测的患者中，雄激素受体阴性、雌激素受体阴性肿瘤患者的5年无复发生存率为75%，雄激素受体阴性、雌激素受体阳性患者的5年无复发生存率为50%，而雄激素受体阳性、雌激素受体阳性和雄激素受体阳性、雌激素受体阴性患者的5年无复发生存率为0（P = 0.0104）。然而，肝内雄激素或雌激素受体的存在或缺乏与肝内复发无关（P = 0.7534）。因此，雄激素受体与HCC的肝内复发密切相关，而雌激素受体的相关性较弱。正常肝脏中的受体状态与肝内复发无关。
Seventy-eight patients in whom androgen or oestrogen or both, were assayed in hepatocellular (HCC) and the surrounding liver were discharged from hospital after curative resection of the tumour. Intrahepatic recurrence was evaluated retrospectively after 28-128 months follow-up to determine the association with receptor status. Androgen and oestrogen receptors in HCC significantly influenced the intrahepatic recurrence rate. The recurrence-free 5-year survival rate was 55 per cent for patients who had androgen receptor-negative tumours, 24 per cent for oestrogen receptor-negative, 10 per cent for oestrogen receptor-positive and 0 for androgen receptor-positive (P = 0.0322). Recurrence-free 5-year survival in 57 patients who had both receptor assays was 75 per cent for patients who had androgen receptor-negative, oestrogen receptor-negative tumours, 50 per cent for androgen receptor-negative, oestrogen receptor-positive, but 0 for androgen receptor-positive, oestrogen receptor-positive and androgen receptor-positive, oestrogen receptor-negative (P = 0.0104). The presence or absence of androgen or oestrogen receptor in the liver, however, was not associated with intrahepatic recurrence (P = 0.7534). Thus, androgen receptors are strongly associated with intrahepatic recurrence of HCC, while oestrogen receptors are weakly associated. Receptor status in the normal liver was not related to intrahepatic recurrence.