A Systematic Review and Meta-Analysis of Studies Evaluating the Effect of Medication Treatment for Opioid Use Disorder on Infectious Disease Outcomes.
A Systematic Review and Meta-Analysis of Studies Evaluating the Effect of Medication Treatment for Opioid Use Disorder on Infectious Disease Outcomes.
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DOI：
10.1093/ofid/ofab289
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发表时间：
2021-08
影响因子：
4.2
通讯作者：
Springer SA
中科院分区：
文献类型：
--
作者：
McNamara KF;Biondi BE;Hernández-Ramírez RU;Taweh N;Grimshaw AA;Springer SA
阿片类药物的流行助长了传染病的流行。我们确定了阿片类药物使用障碍（mod）药物对阿片类药物使用障碍（OUD）相关传染病治疗结果的影响：抗逆转录病毒治疗（ART）依从性、人类免疫缺陷病毒（HIV）病毒抑制、丙型肝炎病毒（HCV）持续病毒学反应、HCV再感染、新的乙型肝炎病毒感染和感染性心内膜炎相关结果。报告接受OUD治疗的成人与“未”接受OUD治疗的成人的这些传染病结局的文献被纳入。最初的搜索产生了8169篇论文；9份被纳入最终审查。荟萃分析显示，mod与更高的抗逆转录病毒治疗依从性（比值比[OR] = 1.55； 95%可信区间[CI] = 1.12-2.15）和HIV病毒抑制（OR = 2.19; 95% CI = 1.88-2.56）相关。一项研究表明mod与HCV持续病毒学反应呈正相关。有重要的支持将mod与HIV治疗结合起来，以改善HIV （PWH）和OUD患者的病毒抑制。治疗残疾妇女的OUD应是防治阿片类药物和艾滋病毒流行的优先事项。有重要的证据支持将mod与HIV治疗相结合，以改善HIV （PWH）和OUD患者的病毒抑制。治疗残疾妇女的OUD应是防治阿片类药物和艾滋病毒流行的优先事项。
The opioid epidemic has fueled infectious disease epidemics. We determined the impact of medications for opioid use disorder (MOUD) on treatment outcomes of opioid use disorder (OUD)-associated infectious diseases: antiretroviral therapy (ART) adherence, human immunodeficiency virus (HIV) viral suppression, hepatitis C virus (HCV) sustained virologic response, HCV reinfection, new hepatitis B virus infections, and infectious endocarditis-related outcomes. Manuscripts reporting on these infectious disease outcomes in adults with OUD receiving MOUD compared with those with OUD “not” receiving MOUD were included. Initial search yielded 8169 papers; 9 were included in the final review. The meta-analysis revealed that MOUD was associated with greater ART adherence (odds ratio [OR] = 1.55; 95% confidence interval [CI] = 1.12–2.15) and HIV viral suppression (OR = 2.19; 95% CI = 1.88–2.56). One study suggested a positive association between MOUD and HCV sustained virologic response. There is significant support for integrating MOUD with HIV treatment to improve viral suppression among persons with HIV (PWH) and OUD. Treatment of OUD among PWH should be a priority to combat the opioid and HIV epidemics. There is significant support for the integration of MOUD with HIV treatment to improve viral suppression among persons with HIV (PWH) and OUD. Treatment of OUD among PWH should be a priority to combat the opioid and HIV epidemics.
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DOI：
10.1016/s2352-3018(18)30176-0
发表时间：
2018-10
期刊：
The lancet. HIV
影响因子：
--
作者：
Gonsalves GS;Crawford FW
通讯作者：
Crawford FW
影响因子：
33.9
作者：
Hartnett, Kathleen P.;Jackson, Kelly A.;Dumyati, Ghinwa
通讯作者：
Dumyati, Ghinwa
影响因子：
4.2
作者：
Socias, M. Eugenia;Wood, Evan;Milloy, M-J
通讯作者：
Milloy, M-J
影响因子：
11.8
作者：
Rosenthal, Elana S.;Silk, Rachel;Kattakuzhy, Sarah
通讯作者：
Kattakuzhy, Sarah
影响因子：
25.7
作者：
Lalezari, Jacob;Sullivan, J. Greg;Cohen, Daniel E.
通讯作者：
Cohen, Daniel E.