Acute Effect of the Timing of Resistance Exercise and Nutrient Intake on Muscle Protein Breakdown
Acute Effect of the Timing of Resistance Exercise and Nutrient Intake on Muscle Protein Breakdown
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DOI：
10.3390/nu12041177
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发表时间：
2020-04-01
期刊：
影响因子：
5.9
通讯作者：
Hashimoto, Takeshi
中科院分区：
文献类型：
--
作者：
Kume, Wataru;Yasuda, Jun;Hashimoto, Takeshi
背景：结合抗阻运动（RE）和营养素摄入刺激肌肉蛋白质净平衡。然而，目前还不清楚营养摄入的最佳时机是在RE之前还是之后，特别是在肌肉蛋白分解（MPB）以增强肌肉合成代谢反应。本研究的目的是调查大量混合餐（即，营养和蛋白质密集的全食物）之前或之后RE，比较RE没有一餐的MPB急性反应的交叉设计研究。研究方法：8名健康的年轻男性进行了三项试验：（1）RE前进食（Pre），（2）RE后进食（Post），（3）RE无进食（No）。测定血浆胰岛素和MPB标记物3-甲基组氨酸（3-MH）。结果：RE后血浆胰岛素水平的时程变化在Post条件下显著高于Pre和No条件。3-MH浓度的曲线下面积在Post条件下显著低于Pre和No条件。结论：这些结果表明，RE后立即进食大量混合餐可有效抑制早晨MPB。
Background: Combining resistance exercise (RE) with nutrient intake stimulates muscle protein net balance. However, it is still unclear whether the optimal timing of nutrient intake is before or after RE, especially on muscle protein breakdown (MPB) for an augmented muscle anabolic response. The aim of this study was to investigate the effect of a substantial mixed meal (i.e., nutrient- and protein-dense whole foods) before or after RE, compared with RE without a meal on the acute response of MPB in a crossover-design study. Methods: Eight healthy young men performed three trials: (1) meal intake before RE (Pre), (2) meal intake after RE (Post), and (3) RE without meal intake (No). Plasma insulin and 3-methylhistidine (3-MH), an MPB marker, were measured. Results: Time course change in plasma insulin level after RE was significantly higher in the Post condition than in the Pre and No conditions. The area under the curve of 3-MH concentration was significantly lower in the Post condition than in the Pre and No conditions. Conclusions: These results suggest that a substantial mixed meal immediately after RE may effectively suppress MPB in the morning.