Physiological Signaling and Structure of the HGF Receptor MET.
Physiological Signaling and Structure of the HGF Receptor MET.
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DOI：
10.3390/biomedicines3010001
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发表时间：
2014-12-31
期刊：
影响因子：
4.7
通讯作者：
Graziani A
中科院分区：
文献类型：
--
作者：
Baldanzi G;Graziani A
肝细胞生长因子又称散布因子，是一种多功能细胞因子，具有同时触发上皮细胞增殖、运动和存活的独特能力。这些特性的结合导致了靶细胞上皮向间充质转化的诱导，这是胚胎发生的基础，但在转移过程中也被肿瘤细胞利用。肝细胞生长因子受体，MET，是一种原癌基因，也是典型的跨膜酪氨酸激酶受体。在这里，我们讨论了MET的分子结构和肝细胞生长因子驱动的协调上皮细胞增殖、运动和形态发生的生理信号。
The “hepatocyte growth factor” also known as “scatter factor”, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties results in the induction of an epithelial to mesenchymal transition in target cells, fundamental for embryogenesis but also exploited by tumor cells during metastatization. The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis.