Emerging roles of autophagy in metabolism and metabolic disorders.
Emerging roles of autophagy in metabolism and metabolic disorders.
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DOI：
10.1007/s11515-015-1354-2
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
He C
中科院分区：
文献类型：
--
作者：
Rocchi A;He C
全球代谢性疾病的流行是对人类健康的直接威胁。遗传特征、环境因素和生活方式的改变是决定体内代谢功能障碍的主要危险因素。自噬是一种内源性应激诱导的溶酶体降解途径，通过循环大分子和代谢物合成新蛋白质和产生能量，并通过清除受损的蛋白质或细胞器来调节细胞稳态。近年来，越来越多的文献表明，自噬机制的缺陷与胰腺β细胞、肝脏、脂肪组织和肌肉等多种代谢组织的功能障碍有关，并与肥胖和胰岛素抵抗等代谢紊乱有关。本文就自噬在细胞代谢调控中的多种作用及其在代谢性疾病中的可能意义进行综述。
The global prevalence of metabolic disorders is an immediate threat to human health. Genetic features, environmental aspects and lifestyle changes are the major risk factors determining metabolic dysfunction in the body. Autophagy is a housekeeping stress-induced lysosomal degradation pathway, which recycles macromolecules and metabolites for new protein synthesis and energy production and regulates cellular homeostasis by clearance of damaged protein or organelles. Recently, a dramatically increasing number of literatures has shown that defects of the autophagic machinery is associated with dysfunction of multiple metabolic tissues including pancreatic β cells, liver, adipose tissue and muscle, and is implicated in metabolic disorders such as obesity and insulin resistance. Here in this review, we summarize the representative works on these topics and discuss the versatile roles of autophagy in the regulation of cellular metabolism and its possible implication in metabolic diseases.