Physical Frailty Predicts Incident Depressive Symptoms in Elderly People: Prospective Findings From the Obu Study of Health Promotion for the Elderly
Physical Frailty Predicts Incident Depressive Symptoms in Elderly People: Prospective Findings From the Obu Study of Health Promotion for the Elderly
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DOI：
10.1016/j.jamda.2014.08.017
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发表时间：
2015-03-01
影响因子：
7.6
通讯作者：
Suzuki, Takao
中科院分区：
文献类型：
--
作者：
Makizako, Hyuma;Shimada, Hiroyuki;Suzuki, Takao
目的：本研究的目的是确定虚弱是否是基线无抑郁症状的老年人突发抑郁症状的一个重要且独立的预测因子。设计：15个月的前瞻性研究。背景：日本一般社区。参与者：共3025名65岁及以上的社区老年人，基线无抑郁症状。测量：采用自评15项老年抑郁量表评估抑郁症状，评分在基线和15个月时6分或以上。受试者接受结构性访谈以获得人口统计学因素和脆弱状况，并以简易智力状态检查和体能测试为潜在预测因素完成认知测试。结果：在15个月的随访调查中，226名参与者(7.5%)报告了抑郁症状的发展。我们发现虚弱和自评一般健康状况差(调整后的优势比为1.86，95%可信区间为1.30-2.66，P<；0.01)是事件抑郁症状的独立预测因子。在调整人口统计学因素、自评一般健康状况、行为、生活安排、简易精神状态检查、短时体能测验和老年抑郁量表的基线得分后，虚弱的参与者与健壮的参与者发生抑郁症状的优势比为1.86(95%可信区间1.05~3.28，P=0.03)。结论：虚弱和自测一般健康状况差是社区老年人抑郁症状的独立预测因素。(C)2015年AMDA--急性后和长期护理医学学会。
Objective: The purpose of this study was to determine whether frailty is an important and independent predictor of incident depressive symptoms in elderly people without depressive symptoms at baseline.Design: Fifteen-month prospective study.Setting: General community in Japan.Participants: A total of 3025 community-dwelling elderly people aged 65 years or over without depressive symptoms at baseline.Measurements: The self-rated 15-item Geriatric Depression Scale was used to assess symptoms of depression with a score of 6 or more at baseline and 15-month follow-up. Participants underwent a structural interview designed to obtain demographic factors and frailty status, and completed cognitive testing with the Mini-Mental State Examination and physical performance testing with the Short Physical Performance Battery as potential predictors.Results: At a 15-month follow-up survey, 226 participants (7.5%) reported the development of depressive symptoms. We found that frailty and poor self-rated general health (adjusted odds ratio 1.86, 95% confidence interval 1.30-2.66, P < .01) were independent predictors of incident depressive symptoms. The odds ratio for depressive symptoms in participants with frailty compared with robust participants was 1.86 (95% confidence interval 1.05-3.28, P = .03) after adjusting for demographic factors, self-rated general health, behavior, living arrangements, Mini-Mental State Examination, Short Physical Performance Battery, and Geriatric Depression Scale scores at baseline.Conclusions: Our findings suggested that frailty and poor self-rated general health were independent predictors of depressive symptoms in community-dwelling elderly people. (C) 2015 AMDA - The Society for Post-Acute and Long-Term Care Medicine.