Pathological findings in horses dying during an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV-1) infection.
Pathological findings in horses dying during an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV-1) infection.
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麻痹型马科动物疱疹病毒 1 型 (EHV-1) 感染爆发期间死亡的马匹的病理结果。
DOI：
10.1111/j.2042-3306.1992.tb02771.x
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发表时间：
1992
影响因子：
2.2
通讯作者：
A. Blunden
中科院分区：
文献类型：
--
作者：
K. Whitwell;A. Blunden
1988年，一个种马场爆发了马疱疹病毒1型（EHV-1）感染的麻痹型，数只动物死亡。这为进行详细的病理学研究提供了机会，以深入了解这种自发性疾病的发病机制。检查了2只瘫痪母兽、3只马驹、1只流产胎仔及其非瘫痪母兽。通过使用间接免疫过氧化物酶（IP）染色清楚地证明了病毒的内皮嗜性。尸检时，病毒感染的证据在胎仔和马驹中广泛存在，但在马仔中有限或不存在，可能反映了其免疫状态的差异。血管病变存在于马驹和成年马驹的中枢神经系统（CNS）中;它们导致马驹的神经病变极轻微。上呼吸道和下呼吸道的严重变化是马驹的一个特殊特征，其中两只表现出肺部广泛的血管炎和血栓形成。当病毒分离阴性时，IP技术在定位一匹母马CNS中的含抗原细胞中具有重要价值。它还揭示了病毒存在于记录较少的部位，如胰腺，肠道，甲状腺，葡萄膜和鼻孔皮肤。
In 1988 an outbreak of the paralytic form of Equid herpesvirus type 1 (EHV-1) infection occurred on a stud farm and several animals died. This provided an opportunity to perform detailed pathological investigations to gain insights into the pathogenesis of this spontaneous disease. Two paretic mares, three foals, an aborted foetus and its non-paretic dam were examined. The endotheliotropism of the virus was clearly demonstrated by the use of an indirect immunoperoxidase (IP) stain. At autopsy, evidence of viral infection was widespread in the foetus and foals, but limited or absent in the mares, probably reflecting differences in their immune status. Vascular lesions were present in the central nervous system (CNS) of the foals as well as the adults; they resulted in minimal neural lesions in the foals. Severe changes in the upper and lower respiratory tracts were a particular feature in the foals, two of which exhibited extensive vasculitis and thrombosis in the lungs. The IP technique was of great value in locating antigen-containing cells in the CNS of one mare when virus isolation was negative. It also revealed the presence of virus in less well documented sites such as the pancreas, gut, thyroid, uveal tract and the skin of the nares.