The Ectodysplasin and NFκB signalling pathways in odontogenesis
The Ectodysplasin and NFκB signalling pathways in odontogenesis
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DOI：
10.1016/j.archoralbio.2004.11.019
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发表时间：
2005-02-01
影响因子：
3
通讯作者：
Sharpe, PT
中科院分区：
文献类型：
--
作者：
Courtney, JM;Blackburn, J;Sharpe, PT
少汗性外胚层发育不良（HED）是一种先天性疾病，影响外胚层起源的器官，包括牙齿，头发和汗腺。外胞浆异常蛋白（斑纹）、Edar（无下垂）和Edar相关的死亡结构域（Edaradd）（皱褶）缺陷导致人类和小鼠的HED。外胞质异常蛋白是肿瘤坏死因子（TNF）超家族成员，其下游信号由kappa B激酶（IKK）复合物抑制剂和kappa B抑制剂（I kappa B）转导，以激活转录因子NF kappa B。NF kappa B信号传导涉及广泛的细胞过程，在每个阶段，不同家族成员的每种功能都必须受到严格调节。最近的数据已经证明了这种信号通路在牙形成中的重要性，特别是在牙尖的形成中。在这里，我们回顾了最近在我们对牙齿发育中的外发育不良蛋白/NF κ B信号传导的理解方面的进展，特别是IKK复合体的中心环节。(c) 2005 Elsevier Ltd版权所有。
Hypohidrotic ectodermal dysplasia (HED) is a congenital disorder affecting organs of ectodermal origin including teeth, hair and sweat glands. Defects in Ectodysplasin (tabby), Edar (downless) and Edar associated death domain (Edaradd) (crinkled) cause HED in both humans and mice. Ectodysplasin is a tumour necrosis factor (TNF) superfamily member whose downstream signalling is transduced by the inhibitor Of kappa B kinase (IKK) complex and inhibitors of kappa B (I kappa B) to activate the transcription factor NF kappa B. NF kappa B signalling is involved in a wide range of cellular processes and at each stage the different family members must be tightly regulated for each function. Recent data have demonstrated the importance of this signalling pathway in odontogenesis, particularly in the formation of cusps. Here we review recent advances in our understanding of Ectodysplasin/NF kappa B signalling in tooth development and in particular the central rote of the IKK complex. (c) 2005 Elsevier Ltd. All rights reserved.