Stress, cortisol, and B lymphocytes: a novel approach to understanding academic stress and immune function.
Stress, cortisol, and B lymphocytes: a novel approach to understanding academic stress and immune function.
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DOI：
10.3109/10253890.2015.1127913
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ceballos RM
中科院分区：
文献类型：
--
作者：
McGregor BA;Murphy KM;Albano DL;Ceballos RM
动物和人类体外模型表明，应激相关的B淋巴细胞减少是由于糖皮质激素水平高，导致前B细胞从骨髓中出现时凋亡。本研究旨在探讨体内应激、唾液皮质醇与人B淋巴细胞之间的关系。在秋季课程开始和春季初步考试前一周，对一年级研究生（n=22）和社区对照样本（n= 30）进行了焦虑（感知压力、负面情绪、抑郁症状）、淋巴细胞表型和唾液皮质醇的评估。与对照组相比，学生在每个时间点的所有测量中都报告了更大的痛苦，除了基线感知压力。采用具有必要控制变量的层次线性回归来评估学生身份对三种焦虑指标、四种淋巴细胞表型指标以及皮质醇AUC和CAR随时间（T1-T2）的影响。学生状态与CD19+ B淋巴细胞显著下降和皮质醇觉醒反应（CAR）变平有关。CAR的变化与CD19+ B淋巴细胞的减少有关。结果表明，学生身份、CAR平化和CD19+淋巴细胞减少之间存在显著关联。
Animal and human in vitro models suggest that stress-related B lymphocyte decrements are due to high levels of glucocorticoids which cause apoptosis of pre-B-cells as they emerge from the bone marrow. The present study sought to explore the relationships among distress, salivary cortisol and human B lymphocytes in vivo. Distress (perceived stress, negative affect, depressive symptoms), lymphocyte phenotype, and salivary cortisol were assessed among first year graduate students (n=22) and a community control sample (n= 30) at the start of classes in the fall and the week immediately before spring preliminary exams. Compared to controls, students reported greater distress on all measures at each time point except baseline perceived stress. Hierarchical linear regression with necessary control variables was used to assess the effect of student status on the three measures of distress, the four measures of lymphocyte phenotype, and cortisol AUC and CAR over time (T1-T2). Student status was associated with a significant decrease in CD19+ B lymphocytes and flattened cortisol awakening response (CAR). Change in CAR was associated with the decrease in CD19+ B lymphocytes. Results indicated that there are significant associations among student status, flattening of CAR, and decrements in CD19+ lymphocytes.