Motoric neurological soft signs and psychopathological symptoms in schizophrenic psychoses
Motoric neurological soft signs and psychopathological symptoms in schizophrenic psychoses
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DOI：
10.1016/j.psychres.2002.12.003
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发表时间：
2006-06-15
影响因子：
11.3
通讯作者：
Schroeder, Johannes
中科院分区：
文献类型：
--
作者：
Jahn, Thomas;Hubmann, Werner;Schroeder, Johannes
采用简易运动量表（BMS）对82例住院精神分裂症患者的运动神经软体征（NSS）进行调查。为了解决精神病理症状和锥体外系副作用的潜在波动，在亚急性状态下对患者进行检查，平均间隔14天两次。NSS与疾病严重程度、社会功能低下和阴性症状显著相关。在Simpson-Angus量表中，NSS与锥体外系副作用之间存在适度但显著的相关性。给患者开的抗精神病药剂量、迟发性运动障碍和静坐症评分都与NSS没有显著相关性。此外，服用氯氮平和常规抗精神病药的患者的NSS评分没有显著差异。精神病理症状在临床过程中保持稳定或改善的患者，其NSS评分显著降低。这一发现并不适用于那些精神病理症状恶化的患者。我们的研究结果表明，精神分裂症患者的NSS相对独立于抗精神病药的副作用，但它们与精神病理症状的严重程度和持久性以及不良的社会功能有关。2005爱思唯尔爱尔兰有限公司版权所有。
Motoric neurological soft signs (NSS) were investigated by means of the Brief Motor Scale (BMS) in 82 inpatients with DSM-III-R schizophrenic psychoses. To address potential fluctuations of psychopathological symptoms and extrapyramidal side effects, patients were examined in the subacute state, twice at an interval of 14 days on the average. NSS were significantly correlated with severity of illness, lower social functioning, and negative symptoms. Modest, but significant correlations were found between NSS and extrapyramidal side effects as assessed on the Simpson-Angus Scale. Neither the neuroleptic dose prescribed to the patient, nor scores for tardive dyskinesia and akathisia were significantly correlated with NSS. Moreover, NSS scores did not significantly differ between patients receiving clozapine and conventional neuroleptics. Patients in whom psychopathological symptoms remained stable or improved over the clinical course showed a significant reduction of NSS scores. This finding did not apply to those patients in whom psychopathological symptoms deteriorated. Our findings demonstrate that NSS in schizophrenic psychoses are relatively independent of neuroleptic side effects, but they are associated with the severity and persistence of psychopathological symptoms and with poor social functioning. (c) 2005 Elsevier Ireland Ltd. All rights reserved.