UTRdb and UTRsite:: specialized databases of sequences and functional elements of 5′ and 3′ untranslated regions of eukaryotic mRNAs
UTRdb and UTRsite:: specialized databases of sequences and functional elements of 5′ and 3′ untranslated regions of eukaryotic mRNAs
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DOI：
10.1093/nar/28.1.193
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发表时间：
2000-01-01
影响因子：
14.9
通讯作者：
Saccone, C
中科院分区：
文献类型：
--
作者：
Pesole, G;Liuni, S;Saccone, C
真核生物mRNA的5'和3'非翻译区可能在基因表达的调控中起着至关重要的作用，控制mRNA的定位、稳定性和翻译效率。出于这个原因，我们开发了UTRdb，这是一个专门的真核生物mRNA 5'端3'非翻译序列数据库，从冗余中清除。UTRdb条目富含主要数据库中不存在的专门信息，包括已经通过实验分析证明具有某些功能作用的核苷酸序列模式的存在。所有这些模式已被收集在UTR位点数据库中，使得可以搜索任何输入序列以寻找注释的功能基序的存在。此外，UTRdb条目已被注释以寻找重复元件的存在。用于真核生物mRNA的5'和3'非翻译区的检索和功能分析的所有互联网资源可在http://bigarea.area.ba.cnr获得。它：8000/EmbIT/UTRHome/.
The-5' and 3' untranslated regions of eukaryotic mRNAs may play a crucial role in the regulation of gene expression controlling mRNA localization, stability and translational efficiency. For this reason we developed UTRdb, a specialized database of 5' end 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs, Furthermore, UTRdb entries have been annotated for the presence of repetitive elements. All internet resources implemented for retrieval and functional analysis of 5' and 3' untranslated regions of eukaryotic mRNAs are accessible at http://bigarea.area.ba.cnr. it:8000/EmbIT/UTRHome/.