Revaluing the Role of vmPFC in the Acquisition of Pavlovian Threat Conditioning in Humans
Revaluing the Role of vmPFC in the Acquisition of Pavlovian Threat Conditioning in Humans
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DOI：
10.1523/jneurosci.0304-20.2020
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发表时间：
2020-10-28
影响因子：
5.3
通讯作者：
Starita, Francesca
中科院分区：
文献类型：
--
作者：
Battaglia, Simone;Garofalo, Sara;Starita, Francesca
腹内侧前额叶皮层（vmPFC）在人类巴甫洛夫威胁条件反射中的作用主要是消除或逆转先前获得的刺激-结果关联。然而，最近的神经影像学证据质疑这一观点，也显示了在威胁获取过程中vmPFC的活动。在这里，我们调查的休闲作用，vmPFC在收购巴甫洛夫威胁条件反射评估皮肤电导反应（SCR）和陈述性记忆的刺激结果意外事件在一个差分巴甫洛夫威胁条件反射的范例在8例患者的双边vmPFC病变，10个PFC和10个健康的参与者（每组包括女性和男性）。结果显示，vmPFC病变患者在威胁获取过程中未能产生条件SCR，尽管没有证据表明非条件刺激的SCR受损或刺激结果意外事件的陈述性记忆受损。这些结果表明，vmPFC在获得新的学习中起着因果作用，而不仅仅是在以前获得的学习的消失或逆转中，如以前所认为的那样。由于VMPFC在图式相关处理和潜在结构学习中的作用，VMPFC可能需要构建任务的详细表示，这是在威胁获取期间预期非条件刺激时产生持续的条件生理反应所需的。
The role of the ventromedial prefrontal cortex (vmPFC) in human pavlovian threat conditioning has been relegated largely to the extinction or reversal of previously acquired stimulus-outcome associations. However, recent neuroimaging evidence questions this view by also showing activity in the vmPFC during threat acquisition. Here we investigate the casual role of vmPFC in the acquisition of pavlovian threat conditioning by assessing skin conductance response (SCR) and declarative memory of stimulus-outcome contingencies during a differential pavlovian threat-conditioning paradigm in eight patients with a bilateral vmPFC lesion, 10 with a lesion outside PFC and 10 healthy participants (each group included both females and males). Results showed that patients with vmPFC lesion failed to produce a conditioned SCR during threat acquisition, despite no evidence of compromised SCR to unconditioned stimulus or compromised declarative memory for stimulus-outcome contingencies. These results suggest that the vmPFC plays a causal role in the acquisition of new learning and not just in the extinction or reversal of previously acquired learning, as previously thought. Given the role of the vmPFC in schema-related processing and latent structure learning, the vmPFC may be required to construct a detailed representation of the task, which is needed to produce a sustained conditioned physiological response in anticipation of the unconditioned stimulus during threat acquisition.