Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke
Ischemia-Reperfusion Injury After Endovascular Thrombectomy for Ischemic Stroke
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DOI：
10.1161/strokeaha.118.022015
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发表时间：
2018-12-01
期刊：
影响因子：
8.3
通讯作者：
Gory, Benjamin
中科院分区：
文献类型：
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作者：
Gauberti, Maxime;Lapergue, Bertrand;Gory, Benjamin
背景和目的-在缺血性中风的实验模型中，突然再灌注与继发性脑损伤有关，造成最后损伤面积的70%。这是否仍然适用于人类尚不清楚。（抽吸与支架取栓器成功实现血运重建），我们研究了完全再灌注的影响，（定义为改良的脑梗死溶栓3）血管内血栓切除术后对早期病变生长的影响，通过基线和再灌注后1天的弥散加权成像进行评估。在纳入试验的381例患者中，35例实现了完全再灌注，受益于基线和第1天的弥散加权成像，没有明显的出血性转化，因此被纳入本研究。我们发现，在完全再灌注后，基线和第1天之间缺血性病变的中位生长仅为0.9 mL，
Background and Purpose-In experimental models of ischemic stroke, abrupt reperfusion is associated with secondary brain damages, responsible for up to 70% of the final lesion size. Whether this remains true in humans is unknown.Methods-Using data from the ASTER randomized trial (Aspiration vs Stent Retriever for Successful Revascularization), we investigated the effect of complete reperfusion (defined as a modified Thrombolysis In Cerebral Infarction 3) after endovascular thrombectomy on early lesion growth as assessed by diffusion-weighted imaging at baseline and 1 day after reperfusion.Results-Among 381 patients included in the trial, 35 achieved complete reperfusion, benefited from both baseline and day 1 diffusion-weighted imaging, lacked significant hemorrhagic transformation, and were, therefore, included in the present study. We found that the median growth of the ischemic lesion between baseline and day 1 was only 0.9 mL after complete reperfusion, representing