INDUCTION BY ANTI-CD40 ANTIBODY OR SOLUBLE CD40 LIGAND AND CYTOKINES OF IGG, IGA AND IGE PRODUCTION BY B-CELLS FROM PATIENTS WITH X-LINKED HYPER-IGM SYNDROME
INDUCTION BY ANTI-CD40 ANTIBODY OR SOLUBLE CD40 LIGAND AND CYTOKINES OF IGG, IGA AND IGE PRODUCTION BY B-CELLS FROM PATIENTS WITH X-LINKED HYPER-IGM SYNDROME
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DOI：
10.1002/eji.1830230936
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发表时间：
1993-09-01
影响因子：
5.4
通讯作者：
FISCHER, A
中科院分区：
文献类型：
--
作者：
DURANDY, A;SCHIFF, C;FISCHER, A
我们研究了X连锁高IgM综合征（HIGM 1）患者的B淋巴细胞通过CD 40膜受体活化的能力。HIGM 1是由CD 40配体基因突变引起的，导致活化T淋巴细胞膜上的表达缺陷。我们发现，通过抗-CD 40单克隆抗体或可溶性CD 40配体加白细胞介素（IL）-4或IL-10触发B细胞导致B细胞增殖和/或向IgG、伊加和IgE分泌分化。这通过C γ、α和β膜同种型表达的转录以及IgG、伊加和IgE的产生来反映。这些结果证实了B细胞的完整性在患者的HIGM 1免疫缺陷和开辟了新的治疗可能性。
We studied the ability of B lymphocytes from patients with X-linked hyper IgM syndrome (HIGM1) to be activated via the CD40 membrane receptor. HIGM1 is caused by a CD40 ligand gene mutation, leading to defective expression on the membrane of activated T lymphocytes. We found that triggering of B cells by an anti-CD40 monoclonal antibody or the soluble CD40 ligand plus interleukin (IL)-4 or IL-10 led to B cell proliferation and/or differentiation towards IgG, IgA and IgE secretion. This was reflected by transcription of Cgamma, alpha and epsilon membrane isotype expression and IgG, IgA and IgE production. These results confirm the integrity of B cells in patients with the HIGM1 immunodeficiency and open up new therapeutic possibilities.