Cellular and molecular events in the action of antidiuretic hormone.
Cellular and molecular events in the action of antidiuretic hormone.
复制标题
抗利尿激素作用中的细胞和分子事件。
DOI：
10.1038/ki.1996.251
复制
发表时间：
1996
影响因子：
19.6
通讯作者：
Hays,RM
中科院分区：
文献类型：
--
作者：
Hays,RM
抗利尿激素作用中的细胞和分子事件。尿浓缩机制和抗利尿激素（ADH）的作用在20世纪50年代是一个有很大争议的主题。从那时起，我们对ADH的细胞作用的理解取得了稳步进展。我们对携带水通道的囊泡从细胞质移动到顶端膜，存款水通道，然后通过胞吞作用恢复的循环过程有了很好的了解。在全面描述通道本身的结构方面取得了进展。同样，在神经末梢和嗜铬细胞等分泌细胞中，细胞骨架控制和囊泡对接的原理似乎也适用于肾单位。
Cellular and molecular events in the action of antidiuretic hormone.The urinary concentrating mechanism and the action of antidiuretic hormone (ADH) were subjects of great controversy in the 1950's. Since then, steady progress has been made in our understanding of the cellular action of ADH. We have a good picture of the cyclic process by which vesicles carrying water channels move from cytoplasm to apical membrane, deposit water channels, and are then recovered by endocyosis. There is progress towards a complete description of the structure of the channels themselves. As well, in secretory cells such as the nerve terminal and the chromaffin cell, there are principles of cytoskeletal control and vesicle docking that appear to apply to the nephron.