EVOLUTION OF COADAPTATION IN A TWO‐LOCUS EPISTATIC SYSTEM
EVOLUTION OF COADAPTATION IN A TWO‐LOCUS EPISTATIC SYSTEM
复制标题
双位点上位系统中共适应的演化
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
F. Tajima
中科院分区：
文献类型：
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作者：
K. R. Takahasi;F. Tajima
虽然基因组生物学的最新进展极大地增加了我们对基因相互作用对复杂表型发展的贡献的理解，但我们仍然缺乏对上位系统进化过程和机制的普遍共识。即使一个物种中的基因确实整合到相互作用成分的共适应复合体中，简单的加性进化最终也可能导致种群的上位性分化。因此，上位性基因作用的普遍性并不能告诉我们上位性选择在种群分化历史中的作用。为了阐明上位选择在协同适应进化中的贡献，我们研究了两个突变协同作用以增强适应性的固定过程。我们通过扩散分析和模拟表明，上位选择共分离变体本身并不能促进上位系统的进化;相反，中性突变的积累可能起着至关重要的作用，为后代的适应性进化创造了适当的遗传环境。
Abstract Although recent advances in genome biology have dramatically increased our understanding of the contribution of gene interactions to the development of complex phenotypes, we still lack general agreement on the process and mechanisms responsible for the evolution of epistatic systems. Even if genes in a species are indeed integrated into coadapted complexes of interacting components, simple additive evolution may eventually result in epistatic differentiation of populations. Consequently, the prevalence of epistatic gene action does not tell us anything about the role of epistatic selection in the history of population divergence. To elucidate the contribution of epistatic selection in the evolution of coadaptation, we investigate the fixation process of two mutations that interact synergistically to enhance fitness. We show by diffusion analysis and simulations that epistatic selection on cosegregating variants does not by itself promote the evolution of epistatic systems; rather, accumulation of neutral mutations may play a crucial role, creating an appropriate genetic milieu for adaptive evolution in the future generations.
影响因子：
3.3
作者：
H. Innan;W. Stephan
通讯作者：
H. Innan;W. Stephan