Microwave irradiation for accelerating each step for the synthesis of 1,2,4-triazino[5,6-b]indole-3-thiolsand their derivatives from isatin and 5-chloroisatin
Microwave irradiation for accelerating each step for the synthesis of 1,2,4-triazino[5,6-b]indole-3-thiolsand their derivatives from isatin and 5-chloroisatin
复制标题
DOI：
10.1055/s-2004-815437
复制
发表时间：
2004-03-09
期刊：
影响因子：
2
通讯作者：
Hagar, M
中科院分区：
文献类型：
--
作者：
El Ashry, ESH;Ramadan, ES;Hagar, M
用微波辐射加速了Iisatin(1)、5-氯isatin(2)和N-苄基isatin(3)转化为缩氨基硫脲，然后环合成1，2，4-三氮基[5，6-b]吲哚-3-硫醇7和8，以及N-苄基衍生物9。1，7，8和9在微波辐射下也实现了选择性和完全的烷基化反应。
Microwave irradiation has been used to accelerate the conversion of isatin (1), 5-chloroisatin (2), and N-benzylisatin (3) to their thiosemicarbazones and their subsequent cyclization into 1,2,4-triazino[5,6-b]indole-3-thiols 7 and 8; and the N-benzyl derivative 9. Selective and complete alkylation of 1, 7, 8, and 9 has also been achieved under microwave irradiation.