High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model
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DOI：
10.1016/j.neurobiolaging.2008.08.022
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发表时间：
2010-09-01
影响因子：
4.2
通讯作者：
Calon, Frederic
中科院分区：
文献类型：
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作者：
Julien, Carl;Tremblay, Cyntia;Calon, Frederic
探讨阿尔茨海默病(AD)的潜在饮食危险因素。三重转基因(3xTg-AD)小鼠从4到13个月龄暴露于低n-3n-6多不饱和脂肪酸(PUFA)比例的饲料中，无论是低脂(5%w/w)还是高脂(35%w/w)配方，与对照饮食相比，3xTg-AD小鼠额叶皮质的n-3 n-6 PUFA比例与非转基因小鼠相比是降低的，与饮食处理无关。与对照组相比，摄入低n-3n-6PUFA比率的高脂饮食增加了3xTg-AD小鼠顶颞叶皮质匀浆洗涤剂不可溶提取物中的淀粉样β蛋白(Aβ)40和42浓度；低n-3n-6蛹摄取率增加了不溶性tau，而低n-3n-6PUFA比率的高脂饮食也增加了可溶性tau；此外，高脂饮食降低了突触后标志物drebrin的皮质水平。同时留下突触前蛋白突触素。Snap-25和Synaxin 3总体上没有变化，这些结果表明高脂肪摄入量和低n-3蚕蛹摄入量促进了AD样神经病理(C)2008 Elsevier Inc.保留所有权利
To investigate potential dietary risk factors of Alzheimer's disease (AD). triple transgenic (3xTg-AD) mice were exposed from 4 to 13 months of age to diets with a low n-3 n-6 polyunsaturated fatty acid (PUFA) ratio incorporated in either low-fat (5% w/w) or high-fat (35% w/w) formulas and compared with a control diet The n-3 n-6 PUFA ratio was decreased independently of the dietary treatments in the frontal cortex of 3xTg-AD mice compared to non-transgenic littermates. Consumption of a high-fat diet with a low n-3 n-6 PUFA ratio increased amyloid-beta (A beta) 40 and 42 concentrations in detergent-insoluble extracts of parieto-temporal cortex homogenates from 3xTg-AD mice Low n-3 n-6 PUPA intake ratio increased insoluble tau regardless of total fat consumption, whereas high-fat diet incorporating a low n-3 n-6 PUFA ratio also increased soluble tau compared to controls Moreover, the high-fat diet decreased cortical levels of the postsynaptic marker drebrin. while leaving presynaptic proteins synaptophysin. SNAP-25 and syntaxin 3 unchanged Overall, these results suggest that high-fat consumption combined with low n-3 PUPA intake promote AD-like neuropathology (C) 2008 Elsevier Inc All rights reserved