Development of Carbon-Ion Radiotherapy Facilities at NIRS
Development of Carbon-Ion Radiotherapy Facilities at NIRS
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DOI：
10.1109/tasc.2017.2785835
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发表时间：
2018-04
影响因子：
1.8
通讯作者：
Y. Iwata;T. Fujita;T. Fujimoto;T. Furukawa;Y. Hara;K. Kondo;K. Mizushima;T. Murakami;M. Muramatsu;M. Nishiuchi;E. Noda;K. Noda;H. Sakaki;N. Saotome;Y. Saraya;S. Sato;T. Shirai;R. Tansho
中科院分区：
文献类型：
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作者：
Y. Iwata;T. Fujita;T. Fujimoto;T. Furukawa;Y. Hara;K. Kondo;K. Mizushima;T. Murakami;M. Muramatsu;M. Nishiuchi;E. Noda;K. Noda;H. Sakaki;N. Saotome;Y. Saraya;S. Sato;T. Shirai;R. Tansho
自1994年6月以来，国立放射线科学研究所（NIRS）一直在使用来自千叶重离子医疗加速器的高能碳束进行放射治疗，迄今已治疗了10000多名患者。根据前十年的前瞻性临床结果，我们设计了一种用于碳离子放射治疗（CIRT）的紧凑型加速器设备，并从2004年开始进行相关的研究和开发（R&D）工作，以广泛使用CIRT。根据设计和研发工作，已建造了三个CIRT紧凑型设施，并已投入处理运行，此外还有两个设施正在日本建造。为了进一步发展先进的CIRT，我们在NIRS建造了一个新的处理设施。这个新设施配备了三个治疗室;其中两个有水平和垂直固定照射端口，另一个是一个扫描架端口。对于所有端口，采用快速三维光栅扫描照射技术。旋转机架配备了10个组合功能超导磁体，可将能量在E = 430 - 50 MeV/u之间的碳离子以超过±180°的照射角度输送到等中心。2015年9月底完成了超导机架的建造和安装，并于2015年5月开始使用机架进行治疗。目前，我们正在进一步设计下一代紧凑型设施作为未来的项目;超导和激光技术将用于加速器设计。本文介绍了碳离子加速器的发展情况以及未来的研究方向。
Radiotherapy using high-energy carbon beams from the Heavy Ion Medical Accelerator in Chiba has been carried out at the National Institute of Radiological Sciences (NIRS) since June 1994, and more than 10 000 patients have been treated to date. With the prospective clinical results for the first ten years, we designed a compact accelerator facility for carbon-ion radiotherapy (CIRT), and performed related Research and Development (R&D) works for widespread use of CIRT since 2004. Based on the design and the R&D works, three compact facilities for CIRT were constructed and are in treatment operation, and furthermore two facilities are being constructed in Japan. To further develop the sophisticated CIRT, we constructed a new treatment facility at NIRS. This new facility is equipped with three treatment rooms; two of them have both horizontal and vertical fixed-irradiation-ports, and the other is a rotating-gantry port. For all ports, fast three-dimensional raster-scanning irradiation technology is employed. The rotating gantry equips ten combined-function superconducting magnets, and can deliver carbon ions having the energy of between E = 430 and 50 MeV/u to an isocenter with irradiation angles of over ±180°. Construction as well as installation of the superconducting gantry was completed by the end of September 2015, and treatments using the gantry began since May 2015. Presently, we are further designing a next-generation compact facility as a future project; superconducting and laser technologies are to be used for accelerator design. In this paper, we report development of carbon-ion accelerator facilities as well as the future project.