STIMULATORY ACTION OF D-AMPHETAMINE ON THE RESPIRATORY CENTER, AND ITS MEDIATION BY A CENTRAL ALPHA-ADRENERGIC MECHANISM
STIMULATORY ACTION OF D-AMPHETAMINE ON THE RESPIRATORY CENTER, AND ITS MEDIATION BY A CENTRAL ALPHA-ADRENERGIC MECHANISM
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DOI：
10.1016/0028-3908(79)90053-4
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发表时间：
1979-01-01
影响因子：
4.7
通讯作者：
FLOREZ, J
中科院分区：
文献类型：
--
作者：
MEDIAVILLA, A;FERIA, M;FLOREZ, J
在去脑-未麻醉和完整麻醉大鼠中研究了静脉注射苯丙胺的呼吸作用。在两种制剂中，安非他明均诱导呼吸频率、分钟通气量和叹息活动一致增加，而潮气量则不一致地改变。在高剂量安非他明（6.0毫克/公斤）时，呼吸非常快和浅。安非他明将CO2和每分钟通气量之间的关系向左移动，但斜率保持平行。有人提出，安非他明刺激呼吸机制，提供了中断吸气所需的吸气关闭开关。脑室内酚妥拉明（100 μ g）而非普萘洛尔（100 μ g）抑制安非他明（3和6 mg/kg，i. v.）对呼吸的影响，以及对血压的影响。建议中央α-肾上腺素能机制介导安非他明对呼吸中枢的作用，正如它在血管中枢水平介导肾上腺素能药物的作用一样。
The respiratory effects of i.v. amphetamine were studied in decerebrate-unanesthetized and intact anesthetized rats. A consistent increase of respiratory frequency, minute volume and sighing activity was induced by amphetamine in both preparations, whereas the tidal volume was inconsistently modified. At high doses of amphetamine (6.0 mg/kg) the breathing was very fast and shallow. Amphetamine shifted the relationship between CO2 and minute ventilation to the left, but the slope remained parallel. It is proposed that amphetamine stimulates specifically the respiratory mechanisms which provide the inspiratory off-switch required to interrupt inspiration. Intracerebroventricular phentolamine (100 .mu.g), but not propranolol (100 .mu.g), inhibited the stimulatory effects of amphetamine (3 and 6 mg/kg, i.v.) on respiration, as well as the depressant effect on blood pressure. It is suggested that a central .alpha.-adrenergic mechanism mediates the action of amphetamine on the respiratory centers, as it does for the action of adrenergic drugs at the level of the vasomotor center.