Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique
Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique
复制标题
DOI：
10.1364/ao.43.003401
复制
发表时间：
2004-06-10
期刊：
影响因子：
1.9
通讯作者：
Prough, DS
中科院分区：
文献类型：
--
作者：
Esenaliev, RO;Petrov, YY;Prough, DS
总血红蛋白浓度 [Hgb] 的测量是一种血液测试，广泛用于评估门诊患者、住院患者和手术患者，特别是那些接受与大量失血、快速输液和输注浓缩红细胞相关的手术的患者。目前的 [Hgb] 测量技术是侵入性的（需要采血），无法提供实时、连续的监测。我们建议使用光声技术对 [Hgb] 进行无创和连续监测。光声技术的高分辨率可以通过检测和分析动脉或静脉中循环的血液中的短光脉冲引起的光声信号来准确测量[Hgb]。我们设计、构建并在体外（在组织模型和初步体内实验中）测试了一种便携式光声系统，用于监测桡动脉中的 [Hgb]。该系统包括在近红外光谱范围内工作的纳秒激光器和敏感的光声探头，旨在通过皮肤照射桡动脉并检测血液中感应的光声信号。我们的研究结果表明：(1) 传输模式下血液中感应的光声波斜率在 6.2 至 12.4 g/dl 范围内线性依赖于 [Hgb]，(2) 尽管厚度为 1 cm 的浑浊组织模型中存在光学衰减，仍可以检测到光声信号，(3) 光声系统可检测到桡动脉循环血液中感应的信号。这些数据表明光声系统可用于准确、无创、实时、连续的[Hgb]监测。 (C) 2004 年美国光学学会。
Measurement of total hemoglobin concentration [Hgb] is a blood test that is widely used to evaluate outpatients, hospital inpatients, and surgical patients, especially those undergoing surgery associated with extensive blood loss, rapid fluid administration, and transfusion of packed red blood cells. Current techniques for measurement of [Hgb] are invasive (requiring blood sampling) and cannot provide real-time, continuous monitoring. We propose to use an optoacoustic technique for noninvasive and continuous monitoring of [Hgb]. The high resolution of the optoacoustic technique may provide accurate measurement of [Hgb] by detection and analysis of optoacoustic signals induced by short optical pulses in blood circulating in arteries or veins. We designed, built, and tested in vitro (in both tissue phantoms and in preliminary in vivo experiments) a portable optoacoustic system for the monitoring of [Hgb] in the radial artery. The system includes a nanosecond laser operating in the near-infrared spectral range and a sensitive optoacoustic probe designed to irradiate the radial artery through the skin and detect optoacoustic signals induced in blood. Results of our studies demonstrated that (1) the slope of optoacoustic waves induced in blood in the transmission mode is linearly dependent on [Hgb] in the range from 6.2 to 12.4 g/dl, (2) optoacoustic signals can be detected despite optical attenuation in turbid tissue phantoms with a thickness of 1 cm, and (3) the optoacoustic system detects signals induced in blood circulating in the radial artery. These data suggest that the optoacoustic system can be used for accurate, noninvasive, real-time, and continuous monitoring of [Hgb]. (C) 2004 Optical Society of America.