Association between iron status and neurodevelopmental outcomes among VLBW infants
Association between iron status and neurodevelopmental outcomes among VLBW infants
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DOI：
10.1016/j.braindev.2009.12.003
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发表时间：
2010-11-01
影响因子：
1.7
通讯作者：
Shimizu, Toshiaki
中科院分区：
文献类型：
--
作者：
Kon, Noriko;Tanaka, Kyoko;Shimizu, Toshiaki
目的：我们的目的是评估患有和不患有宫外生长受限(EUGR)的婴儿的铁状况和神经发育结果。方法：这项观察性研究评估了38名医学上稳定的早产儿，出生体重低于1500g。通过测定静脉血中Hb、Fe和血清铁蛋白的水平来确定铁的状况。将婴儿分为EUGR组和非EUGR组。在校正的18个月龄时，使用Bayley量表检查神经发育结果，并测量体重、体长和头围。结果：与非EUGR组相比，EUGR组校正后1个月和3个月的Hb水平以及校正后I和9个月的铁含量显著降低。两组之间的MDI评分没有显著差异，但EUGR组矫正后18个月的PDI评分显著低于对照组。我们发现1月龄血清铁水平与18月龄的PDI评分呈正相关。尽管EUGR组的体重和身长较低，但校正后18个月的头围在两组之间没有差异。结论：矫正年龄为18个月的早产儿的发育结局可能受早期营养因素的影响，包括铁的状况。(C)2010年，爱思唯尔出版。
Objective: Our purpose was to evaluate iron status and neurodevelopmental outcomes in infants with and without extrauterine growth restriction (EUGR). Methods: This observational study evaluated 38 medically stable premature infants, with birth weights below 1500 g. Iron status was determined by measuring venous levels of Hb, Fe, and serum ferritin. The infants were divided into EUGR and non-EUGR groups. At a corrected age of 18 months, neurodevelopmental outcomes were checked using the Bayley scales, and body weight, body length, and head circumference were measured. Results: Hb levels at corrected ages of 1 and 3 months and iron at a corrected age of I and 9 months were significantly lower in the EUGR group compared with those of the non-EUGR group. There was no significant difference in the MDI score between the groups, but the PDI score at a corrected age of 18 months was significantly lower in the EUGR group. We found a positive correlation between the serum level of Fe at 1 month of age and PDI score at 18 months of age. Head circumference at a corrected age of 18 months did not differ between two groups, although body weight and length were lower in the EUGR group. Conclusions: Developmental outcome in preterm infants at a corrected age of 18 months may be influenced by nutritional factors, including iron status, during their early life. (C) 2010 Published by Elsevier B.V.