Oxidative Stress and Adult Neurogenesis
Oxidative Stress and Adult Neurogenesis
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氧化应激和成人神经发生。
DOI：
10.1007/s12015-015-9603-y
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发表时间：
2015-10-01
影响因子：
4.8
通讯作者：
Arias-Carrion, Oscar
中科院分区：
文献类型：
--
作者：
Yuan, Ti-Fei;Gu, Simeng;Arias-Carrion, Oscar
越来越多的证据表明，成人神经发生对大脑功能至关重要。ROS作为一种生理机制在成人神经发生过程中积累，而ROS超负荷则在衰老、神经炎症和神经退行性变过程中损害成人神经发生。我们认为，靶向氧化应激为调节成人神经发生和管理不同的脑部疾病提供了一种新的方法。
There is a growing evidence that adult neurogenesis is critical for brain function. The reactive oxygen species (ROS) is accumulated during adult neurogenesis as a physiological mechanism; while ROS overload impairs adult neurogenesis during ageing, neuroinflammation and neurodegeneration. Here we propose that targeting oxidative stress provides a novel way to regulate adult neurogenesis and manage different brain diseases.