Parental administration of antipyretics to children with upper respiratory tract infections without consultation with a physician
Parental administration of antipyretics to children with upper respiratory tract infections without consultation with a physician
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DOI：
10.3325/cmj.2011.52.48
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发表时间：
2011-02-01
影响因子：
1.9
通讯作者：
Barsic, Bruno
中科院分区：
文献类型：
--
作者：
Andabaka, Tea;Globocnik, Tina;Barsic, Bruno
目的 评估父母或监护人在未咨询医生的情况下对上呼吸道感染（URTI）儿童使用退烧药的情况，并比较接受退烧药治疗的患者和未接受治疗的患者的流行病学和临床特征。 方法 2002年3月至6月，在克罗地亚萨格勒布的三个儿科诊所进行了一项前瞻性观察性研究。共171名2至14岁的儿童，其症状和体征持续时间超过2年。该研究包括持续 2 天以上的 38 摄氏度以上发烧。收集了有关退热药使用情况、患者人口统计学和流行病学特征以及临床体征和症状的数据。结果 29.8% 的患者使用了退热药，主要是扑热息痛。在去日托中心的儿童中（接受治疗的儿童占 49%，未接受治疗的儿童占 70%，P=0.014）和反复发生 URTI 的儿童（接受治疗的儿童占 33.3%，未接受治疗的儿童占 55.8%，P=0.008），其使用频率较低。然而，这种情况在家族中最近患有 URTI 的儿童中更为常见（接受治疗的儿童为 33.3%，未接受治疗的儿童为 7.5%，P < 0.001）。总体而言，在接受退热药治疗的患者中，大多数 URTI 临床体征和症状明显不太明显。 结论 退热药的使用与不太明显的感染临床体征和症状相关，这表明它们具有抗炎活性，但也与嗜睡等负面影响有关。有必要教育家长了解使用退烧药的积极和消极方面以及退烧药物的最佳选择。
Aim To evaluate the administration of antipyretics to children with upper respiratory tract infections (URTI) by their parents or guardians without consultation with physicians, and compare epidemiological and clinical characteristics of patients who received antipyretics and of untreated patients.Methods A prospective observational study was performed in three pediatric clinics in Zagreb, Croatia, from March to June 2002. A total of 171 children aged from 2 to 14 years with symptoms and signs of URTI lasting more than 2 days and fever above 38 C lasting more than 2 days were included in the study. Data were collected on the usage of antipyretics, patients' demographic and epidemiological characteristics, and clinical signs and symptoms.Results Antipyretics, predominantly paracetamol, were used in 29.8% of patients. Their usage was less frequent in children attending day-care centers (49% of treated and 70% of untreated children, P=0.014) and in children with reiterated URTIs (33.3% of treated and 55.8% of untreated children, P=0.008). However, it was more frequent in children with recent URTIs in the family (33.3% of treated and 7.5% of untreated children, P < 0.001). Overall, most clinical signs and symptoms of URTI were notably less pronounced in patients treated with antipyretics.Conclusions Antipyretics use correlated with less pronounced clinical signs and symptoms of infection, which indicates their anti-inflammatory activity, but also with negative effects such as lethargy. It is necessary to educate parents on the positive and negative aspects of antipyretics use and on the optimal choice of an antipyretic drug.