Extracellular vesicles are the Trojan horses of viral infection.
Extracellular vesicles are the Trojan horses of viral infection.
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DOI：
10.1016/j.mib.2016.05.004
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发表时间：
2016-08
影响因子：
5.4
通讯作者：
Altan-Bonnet N
中科院分区：
文献类型：
--
作者：
Altan-Bonnet N
细胞外囊泡是近年来出现的一种新的病毒传播模式，被包膜病毒和非包膜病毒所利用。特别地，无包膜病毒利用宿主产生的细胞外囊泡以非裂解方式离开细胞并隐藏和操纵免疫系统。此外，挑战了长期以来认为病毒作为独立遗传单位的观点，细胞外囊泡使多个病毒颗粒和基因组能够共同进出细胞，这可以促进病毒准种之间的遗传协同性，并增强整个病毒群体的适应性。
Extracellular vesicles have recently emerged as a novel mode of viral propagation exploited by both enveloped and non-enveloped viruses. In particular non-enveloped viruses utilize the hosts' production of extracellular vesicles to exit from cells non-lytically and to hide and manipulate the immune system. Moreover, challenging the long held idea that viruses behave as independent genetic units, extracellular vesicles enable multiple viral particles and genomes to collectively traffic in and out of cells, which can promote genetic cooperativity among viral quasispecies and enhance the fitness of the overall viral population.