Environmental ozone effects in different population subgroups
Environmental ozone effects in different population subgroups
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DOI：
10.1078/1438-4639-00250
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发表时间：
2003-10-01
影响因子：
6
通讯作者：
Nowak, D
中科院分区：
文献类型：
--
作者：
Höppe, P;Peters, A;Nowak, D
研究的目的是获得更多关于臭氧风险群体特征的信息。我们对171人进行了重复的（平均16次）肺功能测试和访谈，这些人属于四个不同的人群亚组（44名健康儿童，43名青少年哮喘患者，43名运动员和41名老年人）。两组均存在明显的NO2复合污染。哮喘患者表现出统计学上显著的臭氧相关增加的OR为眼睛刺激，老年人的鼻子刺激。发现哮喘患者（FVC - 4.3%下午1天滞后，- 4.9%下午2天滞后，- 3.6%上午1天滞后）和儿童（FVC - 3.2%同一上午，PEF - 11.9%同一上午，PEF - 4.6%上午1天滞后）的肺功能显著下降（臭氧增加50 ppb）。然而，在老年人组中，FVC和PEF也有一些显着增加。臭氧反应者在哮喘患者和儿童组中更常见（分别为21%和21%）。18%），而老年人和运动员（均为5%）。结果表明，儿童和哮喘患者有更高的风险是臭氧敏感性，表现出更多的臭氧相关的急性肺功能下降比其他人群。
The study objective was to get more information on characteristics of ozone risk groups. We performed repeated (on average 16 times) lung function tests and interviews with 171 persons belonging to four different population subgroups (44 healthy children, 43 juvenile asthmatics, 43 athletes, and 41 elderly).The environmental half hour mean ozone concentrations ranged from 8 to 99 ppb. For two groups there was significant NO2 co-pollution. The asthmatics showed statistically significant ozone related increased ORs for eye irritations, the elderly for nose irritations. Significant lung function decrements (increase in ozone by 50 ppb) were found for asthmatics (FVC - 4.3% afternoon one day lag, - 4.9% afternoon two day lag, - 3.6% morning one day lag) and children (FVC - 3.2% same morning, PEF - 11.9% same morning, PEF - 4.6% morning one day lag). In the group of elderly, however, there were also some significant FVC and PEF increments. Ozone responders were found more often in the groups of asthmatics and children (21% resp. 18%) compared with elderly and athletes (both 5%). The results suggest that children and asthmatics have a higher risk of being ozone sensitive showing more ozone related acute lung function decrements than other population groups.