Diurnal salivary cortisol in pediatric posttraumatic stress disorder
Diurnal salivary cortisol in pediatric posttraumatic stress disorder
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DOI：
10.1016/s0006-3223(01)01310-5
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发表时间：
2002-04-01
影响因子：
10.6
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Carrion, VG;Weems, CF;Reiss, AL
背景：下丘脑-垂体-肾上腺（HPA）轴参与了创伤后应激障碍（PTSD）的病理生理过程。额外的信息暴露于创伤和经历PTSD症状的儿童基础皮质醇水平的邮件有助于理解这个轴在PTSD.Methods的作用：51名儿童（30名男孩和21名女孩，平均年龄10.7岁）的历史暴露于创伤和PTSD症状进行了比较，与31名年龄和性别匹配的健康对照组。唾液皮质醇从参与者在家庭测量和收集每天四次（早餐前，午餐前，晚餐前，和prebed）连续3 days.Results：临床组表现出显着，升高的皮质醇水平时，与对照组相比。此外，探索性分析显示，女孩PTSD症状有显着，升高皮质醇水平相比，男孩PTSD symptoms.Conclusions：生理反应的儿童历史的创伤和PTSD症状，其特点是提高肾上腺活动。(C)2002生物精神病学学会。
Background: The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of post-traumatic stress disorder (PTSD). Additional information on basal cortisol levels in children exposed to trauma and experiencing PTSD symptoms mail contribute to the understanding of the role of this axis in PTSD.Methods: Fifty-one children (30 boys and 21 girls, mean age 10.7 years) with a history of exposure to trauma and PTSD symptoms were compared with 31 age- and gender-matched healthy control subjects. Salivary cortisol was obtained from participants during home measurements and was collected four times a day (prebreakfast, prelunch, predinner, and prebed) for up to 3 consecutive days.Results: The clinical group demonstrated significantly, elevated cortisol levels when compared with the control group. In addition, exploratory analyses revealed that girls with PTSD symptoms had significantly, elevated cortisol levels when compared with boys with PTSD symptoms.Conclusions: The physiologic response of children with history of trauma and with PTSD symptoms may, be characterized by heightened adrenal activity. (C) 2002 Society of Biological Psychiatry.